4241-66-1

Basic information

• Product Name: 4-iodobenzenesulfonyl fluoride
• CAS NO: 4241-66-1
• Molecular Formula: C₆H₄FIO₂S
• Molecular Weight: 286.0626
• Mol File: 4241-66-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 276.1°C at 760 mmHg
• Flash Point: 120.8°C
• Density: 2.011g/cm³
• Vapor Pressure: 0.00824mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 4-iodobenzenesulfonyl fluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodobenzenesulfonyl fluoride(4241-66-1)
• EPA Substance Registry System: 4-iodobenzenesulfonyl fluoride(4241-66-1)

Safety Data

• Hazardous Substances Data: 4241-66-1(Hazardous Substances Data)

Usage

General Description

4-Iodobenzenesulfonyl fluoride is a chemical compound that consists of a benzene ring with a sulfonyl fluoride group and an iodine atom attached to it. It is commonly used as a building block in organic synthesis and as a reagent in fluorination reactions. 4-iodobenzenesulfonyl fluoride is known for its ability to selectively react with certain functional groups, making it useful in the development of various pharmaceuticals and agrochemicals. It is also used in the manufacturing of dyes and pigments, as well as in the production of specialty chemicals. Due to its reactivity and selectivity, 4-iodobenzenesulfonyl fluoride is a valuable tool in the field of chemical research and development.

Upstream product

• 62830-55-1 2-(4-iodophenyl)hydrazin-1-ium chloride 
• 540-37-4 p-aminoiodobenzene 
• 2751-27-1 4-iodobenzenesulfonyl hydrazide 
• 1514-50-7 4-iodobenzenediazonium tetrafluoroborate 
• 98-61-3 p-Iodobenzenesulfonyl chloride 

Downstream Products

• 35426-72-3 1,4-Benzoldisulfonylfluorid 
• 360-01-0 1-iodo-4-((trifluoromethyl)sulfonyl)benzene 
• 403792-79-0 4-(1,2-dimethylimidazol-5-yl)-2-(4-(fluorosulphonyl)anilino)pyrimidine 

Relevant articles and documents

Copper-catalyzed three-component reaction of arylhydrazine hydrochloride, DABSO, and NFSI for the synthesis of arenesulfonyl fluorides

This paper reports a convenient copper-catalyzed three-component conversion of arylhydrazine hydrochlorides to arenesulfonyl fluorides in good yields under mild conditions, using 1,4-diazabicyclo [2.2.2]octane bis(sulfur dioxide) (DABSO) as a sulfonyl source andN-fluorobenzenesulfonimide (NFSI) as a fluorine source based on a radical sulfur dioxide insertion and fluorination strategy. Notably, arylhydrazine hydrochloride is used as a safe precursor of aryl radicals.

Arenesulfonyl Fluoride Synthesis via Copper-Catalyzed Fluorosulfonylation of Arenediazonium Salts

We report herein a general and practical copper-catalyzed fluorosulfonylation reaction of a wide range of abundant arenediazonium salts to smoothly prepare various arenesulfonyl fluorides using the 1,4-diazabicyclo[2.2.2]octane-bis(sulfur dioxide) adduct as a convenient sulfonyl source in combination with KHF2 as an ideal fluorine source and without the need for additional oxidants. Interestingly, the electronic character of the arene ring in the starting arenediazonium salts has a significant impact on the reaction mechanistic pathway.

Ascertaining the suitability of aryl sulfonyl fluorides for [18F]radiochemistry applications: A systematic investigation using microfluidics

Optimization of [18F]radiolabeling conditions and subsequent stability analysis in mobile phase, PBS buffer, and rat serum of 12 aryl sulfonyl chloride precursors with various substituents (electron-withdrawing groups, electron-donating groups, increased steric bulk, heterocyclic) were performed using an Advion NanoTek Microfluidic Synthesis System. A comparison of radiochemical yields and reaction times for a microfluidics device versus a conventional reaction vessel is reported. [18F]Radiolabeling of sulfonyl chlorides in the presence of competing nucleophiles, H-bond donors, and water was also assessed and demonstrated the versatility and potential utility of [18F]sulfonyl fluorides as synthons for indirect radiolabeling. Published 2013 by the American Chemical Society.