42466-67-1Relevant articles and documents
SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS
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Page/Page column 78-79, (2018/12/03)
The present application relates to substituted fused heteroaryl and heterocyclic compounds, useful as nicotinamide adenine dinucleotide phosphate oxidase inhibitors (NADPH oxidase inhibitors), processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by NADPH oxidase. (Formula I)
Condensation of ethyl (ethoxymethylene)cyanoacetate with Acyl- and diphenylphosphinylhydrazines
Bagrov
, p. 422 - 425 (2007/10/03)
Condensation of ethyl (ethoxymethylene)cyanoacetate with hydrazides of diphenylphosphinic acid and aliphatic and aromatic acids in ethanol involves exclusively the ethoxymethylene group and yields the corresponding ethyl 3-oxo-2-cyanopropanoate hydrazones. These compounds exist in the crystalline state and in solutions in the form of the enehydrazine tautomer in which the configurational equilibrium is determined by the nature of substituent in the hydrazine moiety.