4248-21-9

Basic information

• Product Name: ETHYLHEXYLCARBAMATE
• Synonyms: ETHYLHEXYLCARBAMATE
• CAS NO: 4248-21-9
• Molecular Formula: C9H19NO2
• Molecular Weight: 173.29
• Mol File: 4248-21-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 247.42°C (estimate)
• Flash Point: 100.7°C
• Appearance: /
• Density: 0.9221 (estimate)
• Vapor Pressure: 0.00718mmHg at 25°C
• Refractive Index: 1.4215 (estimate)
• CAS DataBase Reference: ETHYLHEXYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYLHEXYLCARBAMATE(4248-21-9)
• EPA Substance Registry System: ETHYLHEXYLCARBAMATE(4248-21-9)

Safety Data

• Hazardous Substances Data: 4248-21-9(Hazardous Substances Data)

Usage

General Description

Ethylhexylcarbamate, also known as EHC, is a chemical compound commonly used as a preservative in a variety of personal care products suchjson skin care, hair care, and sunscreen. It functions as a broad-spectrum antimicrobial agent, helping to prevent the growth of bacteria, yeast, and mold in these products. EHC is often preferred as a preservative due to its effectiveness at low concentrations, as well as its low potential for causing skin irritation or sensitization. However, there have been concerns about potential health risks associated with long-term exposure to EHC, and some regulatory agencies have restricted its use in certain products. Overall, while EHC serves an important role in ensuring the safety and stability of personal care products, its potential health effects should be carefully considered in product formulation and regulation.

InChI:InChI=1/C9H19NO2/c1-3-5-6-8(4-2)7-12-9(10)11/h8H,3-7H2,1-2H3,(H2,10,11)

Upstream product

• 75-44-5 phosgene 
• 104-76-7 2-Ethylhexyl alcohol 
• 57-13-6 urea 
• 51-79-6 urethane 
• 917-61-3 sodium isocyanate 
• 24468-13-1 2-Ethylhexyl chloroformate 

Downstream Products

• 62724-16-7 2-ethylhexyloxycarbonyl isocyanate 

Relevant articles and documents

Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates

A novel class of 19 carbamates was synthesized, and their anticonvulsant activity was comparatively evaluated in the rat maximal electroshock (MES) and subcutaneous metrazol (scMet) seizure tests and pilocarpine-induced status epilepticus (SE) model. In spite of the alkyl-carbamates' close structural features, only compounds 34, 38, and 40 were active at the MES test. The analogues 2-ethyl-3-methyl-butyl-carbamate (34) and 2-ethyl-3-methyl-pentyl- carbamate (38) also exhibited potent activity in the pilocarpine-SE model 30 min postseizure onset. Extending the aliphatic side chains of homologous carbamates from 7 to 8 (34 to 35) and from 8 to 9 carbons in the homologues 38 and 43 decreased the activity in the pilocarpine-SE model from ED50 = 81 mg/kg (34) to 94 mg/kg (35) and from 96 mg/kg (38) to 114 mg/kg (43), respectively. The most potent carbamate, phenyl-ethyl-carbamate (47) (MES ED50 = 16 mg/kg) contains an aromatic moiety in its structure. Compounds 34, 38, 40, and 47 offer the optimal efficacy-safety profile and, consequently, are promising candidates for development as new antiepileptics.

Research in dipropylacetic series. XII. Aliphatic ramified acids and alcohols with anticonvulsant activity

Previous results obtained about 2 propyl pentanoic acid (dipropylacetic or DPA) have been extended to other dialkylalkanoic acids having less than 14 carbon atoms and to some of their precursors (alcohols) or derivatives (amides). The effect of lengthening the chain bonding between the carbon bearing the two alkyl chains and the functional carbon on about 50 molecules is discussed. The anticonvulsant activity's length and strength often increases when lengthening that chain.