425-87-6

Basic information

• Product Name: 2-CHLORO-1,1,2-TRIFLUOROETHYL METHYL ETHER
• Synonyms: 2-CHLORO-1,1,2-TRIFLUOROETHYL METHYL ETHER;2-Chloro-1,1,2-trifluoroethyl methyl ether 97%;2-Chloro-1,1,2-trifluoroethylmethylether97%;(1,1,2-Trifluoro-2-chloroethyl)(methyl) ether;1,1,2-Trifluoro-2-chloro-1-methoxyethane;Methyl 1,1,2-trifluoro-2-chloroethyl ether;Methyl 2-chloro-1,1,2-trifluoroethyl ether;2-Chloro-1,1,2-trifluoroethyl methyl ether 9
• CAS NO: 425-87-6
• Molecular Formula: C₃H₄ClF₃O
• Molecular Weight: 148.51
• EINECS: 207-038-9
• Mol File: 425-87-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: -92.5°C
• Boiling Point: 65°C 630mm
• Flash Point: 66°C
• Appearance: /
• Density: 1,364 g/cm3
• Refractive Index: 1.334
• CAS DataBase Reference: 2-CHLORO-1,1,2-TRIFLUOROETHYL METHYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-1,1,2-TRIFLUOROETHYL METHYL ETHER(425-87-6)
• EPA Substance Registry System: 2-CHLORO-1,1,2-TRIFLUOROETHYL METHYL ETHER(425-87-6)

Safety Data

• Hazard Codes: F
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 1992
• RTECS: KN6825000
• HazardClass: 3/6.1
• PackingGroup: III
• Hazardous Substances Data: 425-87-6(Hazardous Substances Data)

Usage

General Description

2-CHLORO-1,1,2-TRIFLUOROETHYL METHYL ETHER is a chemical compound with the formula C3H4ClF3O. It is a colorless, volatile liquid that is used as a solvent in various industrial applications, such as in the production of pharmaceuticals and agrochemicals. It is also used as an intermediate in the synthesis of other chemicals. 2-CHLORO-1,1,2-TRIFLUOROETHYL METHYL ETHER is highly reactive and can present risks if not handled properly, as exposure to the vapors or skin contact can cause irritation and other adverse health effects. Additionally, it is important to note that this compound may be harmful or fatal if swallowed or inhaled, and it should be handled with caution and in accordance with safety regulations.

InChI:InChI=1/C3H4ClF3O/c1-8-3(6,7)2(4)5/h2H,1H3

Upstream product

• 67-56-1 methanol 
• 79-38-9 Chlorotrifluoroethylene 
• 76-13-1 1,1,2-Trichloro-1,2,2-trifluoroethane 
• 124-41-4 sodium methylate 

Downstream Products

• 116-54-1 dichloroacetic acid methyl ester 
• 460-99-1 (2-chloro-1,1,2-trifluoroethyl)trichloromethylether 
• 428-73-9 (2,2-dichloro-1,1,2-trifluoroethyl)trichloromethylether 
• 32776-56-0 2,2-dichloro-1,1,2-trifluoroethyl chloromethyl ether 
• 74-87-3 methylene chloride 
• 593-53-3 Methyl fluoride 
• 359-34-2 chlorofluoroacetyl fluoride 
• 428-96-6 (2-chloro-1,1,2-trifluoroethyl)dichloromethylether 
• 428-92-2 2-chloro-1,1,2-trifluoroethyl chloromethyl ether 
• 29771-98-0 dichloromethyl(2,2-dichloro-1,1,2-trifluoroethyl)ether 

Relevant articles and documents

RADICAL REDUCTION OF C-Cl BONDS IN CHLOROFLUORO ETHERS

Reduction of C-Cl bonds in 2,2-dichloro-1,1,2-trifluoroethyl trichloromethyl ether (I), 2-chloro-1,1,2-trifluoroethyl trichloromethyl ether (II), and 2,2-dichloro-1,1,2-trifluoroethyl dichloromethyl ether (III) with 2-propanol, 2-butanol, cyclohexanol, tetrahydrofuran, diethyl ether, and 1,3-dioxolane initiated photochemically and by radiation has been investigated.Beside the main reduction products - 2-chloro-1,1,2-trifluoroethyl dichloromethyl ether (IV) and 2-chloro-1,1,2-trifluoroethyl chloromethyl ether (V) - it was also possible to prove the formation of 1,2-dichloro-1,2-bis(2-chloro-1,1,2-trifluoroethoxyethane) (VI), 1-chloro-1,2-bis(2-chloro-1,1,2-trifluoroethoxy)ethene (VII), and 1,2-dichloro-1,2-bis(2-chloro-1,1,2-trifluoroethoxy)ethene (VIII).The structure of products was confirmed by elemental analysis, MS, IR, 1H NMR and 19F NMR spectra and by GLC comparison of the elution times with those of the standards.The relative reduction ability of the solvents used and the reduction rate order of C-Cl bonds in the compounds (CCl3 > CFCl2 > CHCl2 and CFClH) are given.

A Facile Synthesis of Fluorochlorobromoacetic Acid

Fluorochlorobromoacetic acid was synthesized in the sequence of four steps from 1,1,2-trifluoro-2-chloroethylene in an overall yield of approximately 25percent. 1,1,2-Trifluoro-2-chloroethylene was first allowed to react with sodium methoxide to form 1,2-difluoro-1-chloro-2-methoxyethylene, which was then brominated with elemental bromine and the reaction product treated with concentrated sulfuric acid to give methyl fluorochlorobromoacetate.This compound was hydrolized with a diluted sodium hydroxide solution to fluorochlorobromoacetic acid.