425-99-0

Basic information

• Product Name: 2,2-DIFLUOROMALONAMIDE
• Synonyms: 2,2-DIFLUOROMALONAMIDE;2,2-Difluoromalonamide 90%;2,2-Difluoromalonamide90%;2,2-difluoropropanediamide;2,2-Difluoropropane-1,3-diamide;Propanediamide,2,2-difluoro-;2,2-Difluoromalonamide(WX619223)
• CAS NO: 425-99-0
• Molecular Formula: C3H4F2N2O2
• Molecular Weight: 138.07
• EINECS: 279-252-0
• Mol File: 425-99-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 206-207°C
• Boiling Point: 223.5°Cat760mmHg
• Flash Point: 99.9°C
• Appearance: /
• Density: 1.238g/cm³
• Vapor Pressure: 9.84E-08mmHg at 25°C
• Refractive Index: 1.429
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.85±0.50(Predicted)
• CAS DataBase Reference: 2,2-DIFLUOROMALONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIFLUOROMALONAMIDE(425-99-0)
• EPA Substance Registry System: 2,2-DIFLUOROMALONAMIDE(425-99-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 425-99-0(Hazardous Substances Data)

Usage

Uses

2,2-Difluoromalonamide is a useful reagent for the synthesis of fluorine-containing endothiopeptide analogs.

InChI:InChI=1/C3H4F2N2O2/c4-3(5,1(6)8)2(7)9/h(H2,6,8)(H2,7,9)

Upstream product

• 425-98-9 chlorure de difluoromalonyle 
• 379-95-3 dimethyl 2,2-difluoro-malonate 
• 680-65-9 diethyl 2,2-difluoromalonate 

Relevant articles and documents

NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND USE

Disclosed are a nitrogenous heterocyclic compound, intermediates, a preparation method, a composition and use thereof. The nitrogenous heterocyclic compound in the present invention is as shown in formula I. The compound has a high inhibitory activity towards ErbB2 tyrosine kinase and a relatively good inhibitory activity towards human breast cancer BT-474 and human gastric cancer cell NCI-N87 which express ErbB2 at a high level, and at the same time has a relatively weak inhibitory activity towards EGFR kinase. Namely, the compound is a highly selective small-molecule inhibitor targeted at ErbB2, and hence it has a high degree of safety, and can effectively enlarge the safety window in the process of taking the drug.

INHIBITORS OF BETA-SECRETASE

The present invention relates to compounds represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Definitions for the variables are provided herein.