42520-09-2Relevant articles and documents
DISSYMMETRY OF CERTAIN SUBSTITUTED DIPYRIDOTETRAAZAPENTALENES
Pereira, David E.,Clauson, Gary L.,Leonard, Nelson J.
, p. 4931 - 4946 (1987)
In a two-step synthesis from staring amines, a series of compounds has been prepared in which steric crowding (1b,c,d,f) was introduced into the "bay region" of pyridoimidazoimidazopyridine (1a).This forces the tetracyclic ring system into non-planarity.Two hexa-heterohelicenes 2a and b were prepared that incorporate the 1,3,4,6-tetraazapentalene ring system and provide molecular crowding in the "bay region" due to the terminal rings, which similarly distort the hexacyclic ring system from planarity.Single crystal X-ray structure determinations revealed that the compounds (1b,c,d,f,2a and b) exist as enantiomeric pairs in the crystalline state.
12-hetero substituted 6,11-ethano-6,11-dihydrobenzo (b) quinolizinium salts and compositions and method of use thereof
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, (2008/06/13)
1-Hetero substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.
13C NMR study of the structures of some acyclic and cyclic ketene acetals
Taskinen,Pentikaeinen
, p. 2365 - 2370 (2007/10/04)
A 13C NMR study of the spatial structures of some acyclic and cyclic ketene acetals (for example, ketene dimethyl acetal and 2-methylene-1,3-dioxolane) has been carried out. The conclusions obtained are based on observation of the effect of structural changes on the 13C NMR chemical shift of the β carbon on the ketene moity. Since the extent of p-π conjugation and hence the 13C chemical shift of this carbon depend on the spatial orientation of the alkoxy groups about the O-C(sp2) bonds, the shift concerned may be used as a measure of the planarity of the system. The most stable retamers of ketene dimethyl acetal are s-cis,s-cis (planar) and s-cis,gauche (slightly nonplanar), in the order of decreasing stability. For ketene dialkyl acetals, the relative stability of the planar s-cis,s-cis form decreases with increasing bulkiness of the alkyl groups, but at least for primary and secondary alkyl groups, the s-cis,s-cis rotamer appears to be the most favored species. The conformations of 5- to 8-membered cyclic ketene acetals are discussed and compared with those of the corresponding cyclic vinyl ethers and hydrocarbons.