425379-16-4

Basic information

• Product Name: 2-BROMO-3-FLUOROBENZONITRILE
• Synonyms: 2-Bromo-3-fluorobenzonitrile99%
• CAS NO: 425379-16-4
• Molecular Formula: C₇H₃BrFN
• Molecular Weight: 200.02
• Product Categories: Nitrile;Aryl;Organohalides
• Mol File: 425379-16-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 60.2-61.3°C
• Boiling Point: 252.8 °C at 760 mmHg
• Flash Point: 106.7 °C
• Appearance: /
• Density: 1.69 g/cm³
• Vapor Pressure: 0.0189mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-BROMO-3-FLUOROBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-3-FLUOROBENZONITRILE(425379-16-4)
• EPA Substance Registry System: 2-BROMO-3-FLUOROBENZONITRILE(425379-16-4)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 425379-16-4(Hazardous Substances Data)

Usage

Chemical Properties

off-white crystalline

InChI:InChI=1/C7H3BrFN/c8-7-5(4-10)2-1-3-6(7)9/h1-3H

Upstream product

• 21524-39-0 2,3-difluorobenzonitrile 
• 115661-37-5 2-amino-3-fluorobenzonitrile 
• 656235-44-8 (2-cyano-6-fluorophenyl)boronic acid 
• 403-54-3 m-Fluorobenzonitrile 

Downstream Products

• 425379-21-1 5'-bromo-6,2'-difluorobiphenyl-2-carbonitrile 
• 1606162-71-3 3-fluoro-2-(4-hexyl-2-hydroxyphenoxy)benzonitrile 
• 1606162-70-2 3-fluoro-2-(4-hexyl-2-hydroxyphenoxy)benzimidamide 
• 1287738-90-2 2',6-difluoro-5'-(5-(2-hydroxypropan-2-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-2-carbonitrile 
• 1287738-81-1 2',6-difluoro-5'-(5-(2-hydroxy-1,1,1,3,3,3-d6-propan-2-yl)-1H-benzo[d]imidazol-1-yl)-biphenyl-2-carbonitrile 
• 1287738-83-3 5'-(5-tert-butyl-d9-1H-benzo[d]imidazol-1-yl)-2',6-difluorobiphenyl-2-carbonitrile 
• 1287739-55-2 C₂₃H₁₀⁽²⁾H₉F₂N₃O₂ 
• 1287738-95-7 5'-(5-tert-butyl-1H-benzo[d]imidazol-1-yl)-2',6-difluorobiphenyl-2-carbonitrile 
• 1287739-91-6 5'-(4-tert-butyl-2-nitrophenylamino)-2',6-difluorobiphenyl-2-carbonitrile 
• 624741-47-5 3-fluoro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzonitrile 
• 1370251-92-5 8-phenoxyquinazoline-2,4-diamine 
• 1261816-95-8 2-bromo-3-methoxybenzonitrile 
• 1293285-68-3 3-fluoro-2-(1H-pyrazol-5-yl)benzoic acid 
• 1293285-70-7 3-fluoro-2-(1H-pyrazol-5-yl)benzonitrile 

Relevant articles and documents

Discovery of imidazo[1,2-b][1,2,4]triazines as GABAA α2/3 subtype selective agonists for the treatment of anxiety

The identification of a series of imidazo[1,2-b][1,2,4]triazines with high affinity and functional selectivity for the GABAA α3-containing receptor subtype is described, leading to the identification of a clinical candidate, 11. Compound 11 shows good bioavailability and half-life in preclinical species, and it is a nonsedating anxiolytic in both rat and squirrel monkey behavioral models.

Facile Synthesis of 2-Bromo-3-fluorobenzonitrile: An Application and Study of the Halodeboronation of Aryl Boronic Acids

A scaleable synthesis of 2-bromo-3-fluorobenzonitrile via the NaOMe-catalyzed bromodeboronation of 2-cyano-6-fluorophenylboronic acid was developed. The generality of this transformation was demonstrated through the halodeboronation of a series of aryl boronic acids. Both aryl bromides and aryl chlorides were formed in good to excellent yields when the corresponding aryl boronic acid was treated with 1,3-dihalo-5,5-dimethylhydantoin and 5 mol % NaOMe.

IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a -NH- linkage, and substituted on the phenyl ring by one or two further substituents as defined herein, being selective ligands for GABAA receptors, in particular having good affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.