426825-66-3

Basic information

• Product Name: 6-Bromo-2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine
• Synonyms: 6-Bromo-2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine, 6-bromo-2-(4-fluorophenyl)-;6-bromo-2-(4-fluoropjhenyl)imidazo[1,2-a]pyridine
• CAS NO: 426825-66-3
• Molecular Formula: C₁₃H₈BrFN₂
• Molecular Weight: 291.1184232
• Mol File: 426825-66-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.55 g/cm³
• CAS DataBase Reference: 6-Bromo-2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine(426825-66-3)
• EPA Substance Registry System: 6-Bromo-2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine(426825-66-3)

Safety Data

• Hazardous Substances Data: 426825-66-3(Hazardous Substances Data)

Usage

General Description

6-Bromo-2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine is a chemical compound that belongs to the imidazo[1,2-a]pyridine class of compounds. It is characterized by a bromine atom at the 6 position, a 2-(4-fluoro-phenyl) group, and an imidazo[1,2-a]pyridine ring system. 6-Bromo-2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine has potential applications in medicinal chemistry and drug discovery due to its ability to interact with biological targets, particularly in the field of oncology and neurology. Its structural features make it a promising candidate for the development of new pharmaceuticals, and its synthesis and properties are the subject of ongoing research and investigation.

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 896885-34-0 1-(4-fluorophenyl)ethan-1-one-O-acetyl oxime 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 329-79-3 1-(4-fluorophenyl)ethanone oxime 

Downstream Products

• 347-12-6 2-(4-fluorophenyl)imidazo[1,2-a]pyridine 
• 1435397-68-4 6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-cyanobenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime 
• 1435397-62-8 6-bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime 
• 1435397-56-0 6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-ethoxybenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime 
• 1435397-50-4 6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-methylbenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime 
• 1435396-25-0 6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime 
• 1435395-83-7 6-bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde oxime 

Relevant articles and documents

CuCl2-catalyzed N[sbnd]O bond cleavage of oxime esters: Approach to imidazoheterocycles and furo[3,2-c]chromenyl fused imidazoles

An articulate approach to a diverse set of imidazoheterocycles in good to high yields via a copper-catalyzed aza-annulation of several oxime esters with a group of 2-amino-azaarenes was developed. The above cyclization reaction probably proceeds via a single electron transfer process which embodies a new technique for creating two new C[sbnd]N bonds for imidazole ring synthesis. Gratifyingly, the implementation of this chemistry could be further stretched to the synthesis of a novel class of fused imidazoles bearing a furo[3,2-c]chromene moiety via a sequential C[sbnd]N bond formation, followed by C(sp2)-H functionalization/5-endo-dig-oxacyclization (C[sbnd]C and C[sbnd]O bonds) of in situ produced fused imidazoles with cyclic enynones in the presence of copper(II) as a π-electrophilic Lewis acid catalyst.

IMIDAZOPYRIDINE COMPOUNDS

The invention relates to compounds of formula (I): and their pharmaceutically acceptable salts and solvates, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment or prevention of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases and immune disorders.

Imidazo[1,2-a]pyridines with potent activity against herpesviruses

Synthesis of a series of 2-aryl-3-pyrimidyl-imidazo[1,2-a]pyridines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the 2-aryl, 3-heteroaryl as well as other imidazopyridine substituents are