42710-52-1Relevant articles and documents
New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam
Bihel, Frédéric J.J.,Justiniano, Héléne,Schmitt, Martine,Hellal, Malik,Ibrahim, Mohamed A.,Lugnier, Claire,Bourguignon, Jean-Jacques
, p. 6567 - 6572 (2011/12/04)
Pharmacophoric comparison between papaverine and tofisopam led to identify three new series of microto sub-micromolar inhibitors of phosphodiesterase-4, including 7,8-dialkoxy-2,3-benzodiazepin-4-one derivatives, 7,8-dialkoxy-1,4- benzodiazepin-2-one derivatives, and dialkoxybenzophenone derivatives.
2-Benzopyran-3-ones Stabilised by Alkoxy Substituents
Bradshaw, David P.,Jones, David W.,Tideswell, John
, p. 169 - 173 (2007/10/02)
In contrast to the corresponding compounds lacking alkoxy substituents, the 2-benzopyran-3-ones 5, 6, 7 and 9 are stable and easily isolated.In contrast to the 6-methoxy derivative 7, the 7-methoxy isomer 8 cannot be isolated; the stabilising effect of th