42791-51-5

Basic information

• Product Name: 2-ACETYL-4-NITROTHIOPHENE
• Synonyms: 2-ACETYL-4-NITROTHIOPHENE;1-(4-Nitrothiophen-2-yl)ethanone
• CAS NO: 42791-51-5
• Molecular Formula: C6H5NO3S
• Molecular Weight: 171.1738
• Mol File: 42791-51-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 280.9 °C at 760 mmHg
• Flash Point: 123.7 °C
• Appearance: /
• Density: 1.399 g/cm³
• Vapor Pressure: 0.00368mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-ACETYL-4-NITROTHIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETYL-4-NITROTHIOPHENE(42791-51-5)
• EPA Substance Registry System: 2-ACETYL-4-NITROTHIOPHENE(42791-51-5)

Safety Data

• Hazardous Substances Data: 42791-51-5(Hazardous Substances Data)

Usage

General Description

2-Acetyl-4-nitrothiophene is a chemical compound with the molecular formula C6H5NO3S. It is a yellow crystalline solid with a strong odor. It is commonly used in organic synthesis and pharmaceutical research as a building block for the production of various drugs and other bioactive molecules. 2-Acetyl-4-nitrothiophene is known for its strong odor and is classified as a hazardous substance. It should be handled and stored with caution, following proper safety protocols to minimize the risk of exposure and potential harm. Due to its potential uses in the pharmaceutical industry, 2-Acetyl-4-nitrothiophene is subject to strict regulations and control to prevent misuse and ensure safe handling.

InChI:InChI=1/C6H5NO3S/c1-4(8)6-2-5(3-11-6)7(9)10/h2-3H,1H3

Upstream product

• 13138-70-0 4-nitro-2-thiophenecarboxylic acid 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 88-15-3 2-Acetylthiophene 
• 24647-78-7 methyl 4-nitrothiophene-2-carboxylate 
• 4565-29-1 5-acetylthiophene-2-carbaldehyde 
• 108-24-7 acetic anhydride 

Downstream Products

• 92576-84-6 1-(4-nitro-[2]thienyl)-ethanone-(4-bromo-phenylhydrazone) 
• 692889-40-0 2-acetyl-4-amino-thiophene 

Relevant articles and documents

Ethylammonium nitrate (EAN)/Tf2O and EAN/TFAA: Ionic liquid based systems for aromatic nitration

Acting as in situ sources of triflyl nitrate (TfONO2) and trifluoroacetyl nitrate (CF3COONO2), the EAN/Tf 2O and EAN/TFAA systems, generated via metathesis in the readily available ethylammonium nitrate (EAN) ionic liquid as solvent, are powerful electrophilic nitrating reagents for a wide variety of aromatic and heteroaromatic compounds. Comparative nitration experiments indicate that EAN/Tf2O is superior to EAN/TFAA for nitration of strongly deactivated systems. Both systems exhibit low substrate selectivity (K T/KB = 5-10) in (Figure presented) between values reported for covalent nitrates and preformed nitronium salts.

Synthesis and antibacterial activity of 4,7-dihydro-4-ethyl-7-oxothieno(3,2-b)pyridine-6-carboxylic acids

The synthesis of some new 4,7-dihydro-4-ethyl-7-oxothieno(3,2-b)pyridine-6-carboxylic acids with various substituents on position 2 is described. The evaluation of the anti-bacterial activity of some compounds shows an activity different to those of the thieno(2,3-b)pyridine series.

The Synthesis of 2-Heteroarylimidazopyridin-3-ols and Related Compounds

A reaction between pyridin-2-amine 1-oxides and phenalcyl bromides has been extended to some bromoacetyl heteroaromatic compounds to form the title compounds.The reaction of some 2-aminodiazine 1-oxides with phenacyl bromides has also been studied.The imidazopyrimidne and imidazophthalazine systems have been prepared but reaction of pyrazin-2-amine 1-oxide did not give the desired cyclization.