42907-96-0

Basic information

• Product Name: β-(2-hydroxy-4-methoxybenzoyl)propionic acid methyl ester
• Synonyms: β-(2-hydroxy-4-methoxybenzoyl)propionic acid methyl ester
• CAS NO: 42907-96-0
• Molecular Weight: 238.24
• Mol File: 42907-96-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: β-(2-hydroxy-4-methoxybenzoyl)propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: β-(2-hydroxy-4-methoxybenzoyl)propionic acid methyl ester(42907-96-0)
• EPA Substance Registry System: β-(2-hydroxy-4-methoxybenzoyl)propionic acid methyl ester(42907-96-0)

Safety Data

• Hazardous Substances Data: 42907-96-0(Hazardous Substances Data)

Upstream product

• 14563-41-8 4-(2,4-dimethoxy-phenyl)-4-oxo-butyric acid methyl ester 
• 151-10-0 1,3-Dimethoxybenzene 
• 186581-53-3 diazomethane 
• 13335-54-1 4-(2,4-dihydroxy-phenyl)-4-oxo-butyric acid 
• 67-56-1 methanol 
• 14617-02-8 4-(2-hydroxy-4-methoxyphenyl)-4-oxobutanoic acid 

Downstream Products

• 16290-14-5 1,4-bis(2,4-dihydroxyphenyl)butanedione 
• 132124-44-8 6-(2-hydroxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one 
• 14617-06-2 3-(2',4'-dimethoxybenzoyl)propionic acid 

Relevant articles and documents

Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors

The involvement of μ-calpain in neurological disorders, such as stroke and Alzheimer's disease has attracted considerable interest in the use of calpain inhibitors as therapeutic agents. 4-Aryl-4-oxobutanoic acid amide derivatives 4 were designed as acyclic variants of μ-calpain inhibitory chromone and quinolinone derivatives. Of the compounds synthesized, 4c-2, which possesses a 2-methoxymethoxy group at the phenyl ring and a primary amide at the warhead region most potently inhibited μ-calpain (IC50 = 0.34 μM). Our findings suggest that the 4-aryl-4-oxobutanoic acid amide derivatives should be considered as a new family of μ-calpain inhibitors.