4298-15-1

Basic information

• Product Name: DESETHYL HYDROXY CHLOROQUINE
• Synonyms: 2-[[4-[(7-Chloro-4-quinolyl)amino]pentyl]amino]ethanol;2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol;DESETHYL HYDROXY CHLOROQUINE;cletoquine
• CAS NO: 4298-15-1
• Molecular Formula: C₁₆H₂₂ClN₃O
• Molecular Weight: 307.82
• EINECS: 1308068-626-2
• Product Categories: Metabolite
• Mol File: 4298-15-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 514.7 °C at 760 mmHg
• Flash Point: 265.1 °C
• Appearance: /
• Density: 1.212 g/cm³
• Vapor Pressure: 2.03E-11mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
• PKA: 14.80±0.10(Predicted)
• CAS DataBase Reference: DESETHYL HYDROXY CHLOROQUINE(CAS DataBase Reference)
• NIST Chemistry Reference: DESETHYL HYDROXY CHLOROQUINE(4298-15-1)
• EPA Substance Registry System: DESETHYL HYDROXY CHLOROQUINE(4298-15-1)

Safety Data

• Hazardous Substances Data: 4298-15-1(Hazardous Substances Data)

Usage

Uses

Cletoquine is a metabolite of Hydroxychloroquine (H916900), an antimalarial; antirheumatic; lupus erythematosus suppressant.

InChI:InChI=1/C16H22ClN3O/c1-12(3-2-7-18-9-10-21)20-15-6-8-19-16-11-13(17)4-5-14(15)16/h4-6,8,11-12,18,21H,2-3,7,9-10H2,1H3,(H,19,20)

Upstream product

• 141-43-5 ethanolamine 
• 10500-64-8 4-(7-chloro-quinolin-4-ylamino)-pentan-1-ol 
• 86-98-6 4,7-dichloroquinoline 
• 927-55-9 (±)-4-amino-1-pentanol 

Relevant articles and documents

Preparation method of hydroxychloroquine impurity

The invention discloses a preparation method of a hydroxychloroquine impurity. 4-amino-1-pentanol taken as a raw material undergoes a five-step reaction to realize synthesis of a hydroxychloroquine impurity VIII. The preparation method is reasonable in process design and high in operability, and industrial production can be realized; reagents used in the synthesis method are simple and easy to obtain; the purity of the hydroxychloroquine impurity obtained through the reaction can reach 98% or above, and the total yield can reach 20% or above. The hydroxychloroquine impurity prepared by the invention provides an important basis for scientific evaluation of quality, safety and efficiency of hydroxychloroquine.