43009-16-1

Basic information

• Product Name: Carbamodithioic acid, phenyl-, compd. with N,N-diethylethanamine (1:1)
• CAS NO: 43009-16-1
• Molecular Formula: C7H7NS2.C6H15N
• Molecular Weight: 270.463
• Mol File: 43009-16-1.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: Carbamodithioic acid, phenyl-, compd. with N,N-diethylethanamine (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamodithioic acid, phenyl-, compd. with N,N-diethylethanamine (1:1)(43009-16-1)
• EPA Substance Registry System: Carbamodithioic acid, phenyl-, compd. with N,N-diethylethanamine (1:1)(43009-16-1)

Safety Data

• Hazardous Substances Data: 43009-16-1(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 121-44-8 triethylamine 
• 62-53-3 aniline 

Downstream Products

• 18334-60-6 4-phenyl-5-phenylimino-3-thio-1,2,4-thiadiazolidine 
• 135472-09-2 5-[(Z)-Cyclohexylimino]-4-phenyl-[1,2,4]dithiazolidine-3-thione 
• 77959-41-2 5-thio-2-phenylimino-4-phenyl-1,3,4-dithiazolidine 
• 135472-08-1 5-[(Z)-Isopropylimino]-4-phenyl-[1,2,4]dithiazolidine-3-thione 
• 103-72-0 phenyl isothiocyanate 
• 94407-77-9 S-phenylthiocarbamoyl-thiocarbonic acid O-ethyl ester 
• 51655-89-1 4,5-dimethyl-3-phenyl-1,3-thiazole-2(3H)-thione 
• 156139-61-6 1-(2,3-dihydro-4-methyl-3-phenyl-2-thioxothiazol-5-yl)-1-ethanone 
• 103-85-5 monophenylthiourea 
• 1227694-77-0 2-(phenylimino)naphtho[2,3-d][1,3]dithiole-4,9-dione 
• 18741-24-7 2-mercapto-3-phenyl-3H-quinazolin-4-one 
• 33174-73-1 3-phenyl-1,3-thiazole-2(3H)-thione 
• 33174-72-0 N-phenyl-4-hydroxy-1,3-thiazolidin-2-thione 
• 14606-38-3 bis-(α-phenyliminobenzyl) sulfide 

Relevant articles and documents

Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway

In order to find new and highly effective anti-tumor drugs with targeted therapeutic effects, a series of novel 4-aminoquinazoline derivatives containing N-phenylacetamide structure were designed, synthesized and evaluated for antitumor activity against four human cancer cell lines (H1975, PC-3, MDA-MB-231 and MGC-803) using MTT assay. The results showed that the compound 19e had the most potent antiproliferative activity against H1975, PC-3, MDA-MB-231 and MGC-803 cell lines. At the same time, compound 19e could significantly inhibit the colony formation and migration of H1975 cells. Compound 19e also arrested the H1975 cell cycle in the G1 phase and mediated cell apoptosis, promoted the accumulation of ROS in H1975 cells. Furthermore, compound 19e exerted antitumor effect in vitro by reducing the expression of anti-apoptotic protein Bcl-2 and increasing the pro-apoptotic protein Bax and p53. Mechanistically, compound 19e could significantly decreased the phosphorylation of EGFR and its downstream protein PI3K in H1975 cells. Which indicated that compound 19e targeted H1975 cell via interfering with EGFR-PI3K signaling pathway. Molecular docking showed that compound 19e could bind into the active pocket of EGFR. Those work suggested that compound 19e would have remarkable implications for further design of anti-tumor agents.

Direct, Microwave-Assisted Synthesis of Isothiocyanates

A microwave-assisted desulfuration of readily available dithiocarbamates, formed in situ from primary amines, leading to target isothiocyanates has been developed. This efficient protocol provides a rapid, environmentally benign route to aliphatic and aromatic isothiocyanates.

Synthesis of novel dithiocarbamates and xanthates using dialkyl azodicarboxylates: S–N bond formation

A one?pot three?component route for the synthesis of a novel category of dithiocarbamates or xanthates is developed by a reaction of in-situ generated dithiocarbamic acids or xanthates with dialkyl azodicarboxylates under mild and catalyst-free conditions. The reaction is characterized by a wide scope, high efficiency and straightforward isolation protocol. The synthetic utility of the dithiocarbamates and xanthates was demonstrated on the preparation of symmetrical and unsymmetrical thioureas, isothiocyanates, and thiocarbamates.