43038-37-5

Basic information

• Product Name: 2-PHENOXYBENZHYDRAZIDE
• Synonyms: 2-Phenoxybenzohydrazide;2-PHENOXYBENZHYDRAZIDE
• CAS NO: 43038-37-5
• Molecular Formula: C₁₃H₁₂N₂O₂
• Molecular Weight: 228.25
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 43038-37-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 99 °C
• Appearance: /
• Density: 1.217 g/cm³
• Refractive Index: 1.612
• Solubility: soluble in Methanol
• PKA: 12.18±0.10(Predicted)
• CAS DataBase Reference: 2-PHENOXYBENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENOXYBENZHYDRAZIDE(43038-37-5)
• EPA Substance Registry System: 2-PHENOXYBENZHYDRAZIDE(43038-37-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-43-36
• Safety Statements: 26-36/37/39-36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 43038-37-5(Hazardous Substances Data)

Usage

General Description

2-Phenoxybenzhydrazide, also known as PBH, is a chemical compound that is used as an insecticide and acaricide. It is primarily used to control a range of pests, including aphids, spider mites, and whiteflies, in various crops such as fruits, vegetables, and ornamental plants. PBH works by inhibiting the growth and development of insect pests, ultimately leading to their death. It is considered to be an effective and relatively safe alternative to conventional insecticides, as it has low toxicity to mammals and other non-target organisms. However, due to its potential impact on beneficial insects and pollinators, as well as its persistence in the environment, careful and responsible use of PBH is recommended.

InChI:InChI=1/C13H12N2O2/c14-15-13(16)11-8-4-5-9-12(11)17-10-6-2-1-3-7-10/h1-9H,14H2,(H,15,16)

Upstream product

• 40501-36-8 2-phenoxybenzoyl chloride 
• 2243-42-7 2-phenoxybenzoic acid 
• 21905-56-6 methyl 2-phenoxybenzoate 
• 41755-76-4 ethyl 2-phenoxybenzoate 

Downstream Products

• 363179-62-8 N-(2-phenoxy-benzoyl)-N'-(toluene-4-sulfonyl)-hydrazine 
• 1122569-47-4 5-(2-phenoxyphenyl)-[1,3,4]oxadiazole-2-thiol 
• 618429-99-5 5-(2-phenoxyphenyl)-2H-1,2,4-triazole-3(4H)-thione 
• 1122569-47-4 C₁₄H₁₀N₂O₂S 
• 107922-64-5 2-phenoxy-benzaldehyde-semicarbazone 
• 19434-34-5 2-(phenoxy)benzaldehyde 
• 618430-11-8 3-ethoxy-5-(2-phenoxy-phenyl)-4H-[1,2,4]triazole 

Relevant articles and documents

Structural design, synthesis and substituent effect of hydrazone-N-acylhydrazones reveal potent immunomodulatory agents

4-(Nitrophenyl)hydrazone derivatives of N-acylhydrazone were synthesized and screened for suppress lymphocyte proliferation and nitrite inhibition in macrophages. Compared to an unsubstituted N-acylhydrazone, active compounds were identified within initial series when hydroxyl, chloride and nitro substituents were employed. Structure-activity relationship was further developed by varying the position of these substituents as well as attaching structurally-related substituents. Changing substituent position revealed a more promising compound series of anti-inflammatory agents. In contrast, an N-methyl group appended to the 4-(nitrophenyl)hydrazone moiety reduced activity. Anti-inflammatory activity of compounds is achieved by modulating IL-1β secretion and prostaglandin E2 synthesis in macrophages and by inhibiting calcineurin phosphatase activity in lymphocytes. Compound SintMed65 was advanced into an acute model of peritonitis in mice, where it inhibited the neutrophil infiltration after being orally administered. In summary, we demonstrated in great details the structural requirements and the underlying mechanism for anti-inflammatory activity of a new family of hydrazone-N-acylhydrazone, which may represent a valuable medicinal chemistry direction for the anti-inflammatory drug development in general.

Synthesis of new thiazolo[3,2-b][1,2,4]triazole-6(5H)-one derivatives as potent analgesic and anti-inflammatory agents

A series of thiazolo[3,2-b][1,2,4]triazole-6(5H)-ones were synthesized and evaluated for their analgesic and anti-inflammatory activities. The structures of these compounds were supported by FT-IR, 1HNMR, and Mass spectra. All of the final comp

NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine recept