430452-27-0

Basic information

• Product Name: C₁₃H₁₅BrClNO₃
• CAS NO: 430452-27-0
• Molecular Weight: 348.624
• Mol File: 430452-27-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₅BrClNO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₅BrClNO₃(430452-27-0)
• EPA Substance Registry System: C₁₃H₁₅BrClNO₃(430452-27-0)

Safety Data

• Hazardous Substances Data: 430452-27-0(Hazardous Substances Data)

Upstream product

• 39089-62-8 2-chloro-N-[(tetrahydrofuran-2-yl)methyl]acetamide 
• 3964-56-5 4-bromo-2-chlorophenol 
• 4795-29-3 TETRAHYDROFURFURYLAMINE 

Relevant articles and documents

Synthesis of benzo[b][1,4]oxazin-3(4H)-ones via smiles rearrangement for antimicrobial activity

The benzo[b][1,4]oxazin-3(4H)-one derivatives, 1a-p, carrying F, Br, and Cl on the benzene ring, or benzyl, cyclohexyl, n-hexyl, and tetrafuryl methylene groups attached to nitrogen atom were synthesized via Smiles rearrangement and assayed in vitro for their antimicrobial activity against Gram-positive, Gram-negative bacteria, and fungi. The antimicrobial activity of the benzo[b][1,4]oxazin-3(4H)-ones showed, on the whole, potency toward all the tested Gram-positive and Gramnegative microorganism (MIC ranging from 16 to 64 lg/ ml), whereas weak effectiveness was exhibited against fungi. Data obtained suggest that fluorine atom in the compounds, 1c, 1f, 1i plays an important role in enhancing the antimicrobial properties of this class of compounds. These observations provide some predictions to design further antimicrobial active compounds prior to their synthesis according to molecular modeling studies.