43073-12-7

Basic information

• Product Name: 4,5-dimethoxybenzene-1,2-dicarbaldehyde
• CAS NO: 43073-12-7
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• Mol File: 43073-12-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 371.4°C at 760 mmHg
• Flash Point: 168.2°C
• Density: 1.207g/cm³
• Vapor Pressure: 1.04E-05mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 4,5-dimethoxybenzene-1,2-dicarbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dimethoxybenzene-1,2-dicarbaldehyde(43073-12-7)
• EPA Substance Registry System: 4,5-dimethoxybenzene-1,2-dicarbaldehyde(43073-12-7)

Safety Data

• Hazardous Substances Data: 43073-12-7(Hazardous Substances Data)

Usage

General Description

4,5-dimethoxybenzene-1,2-dicarbaldehyde, also known as syringaldehyde, is a chemical compound with a benzene ring and two aldehyde functional groups. It is commonly found in various plant sources, particularly in lignin, and is used in the production of vanillin, a popular flavoring agent. Syringaldehyde has been studied for its potential antioxidant and antimicrobial properties, as well as its role in lignin degradation in the environment. It also has potential applications in the pharmaceutical and cosmetic industries due to its aromatic and reactive nature. However, it is important to note that syringaldehyde may have certain toxic or irritant properties, and caution should be exercised when handling or using this compound.

Upstream product

• 22943-99-3 (4,5-dimethoxy-1,2-phenylene)dimethanol 
• 1134-52-7 1,2-Dimethoxy-4,5-bis(chloromethyl)benzene 
• 50-00-0 formaldehyd 
• 93-07-2 Veratric acid 
• 132233-78-4 4,5-dimethoxy-2-(dimethoxymethyl)benzaldehyde 
• 531-88-4 5,6-dimethoxyphthalide 
• 201230-82-2 carbon monoxide 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 14382-91-3 2-hydroxy-4,5-dimethoxybenzaldehyde 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 
• 54370-00-2 2-bromo-4,5-dimethoxybenzyl alcohol 
• 132628-76-3 2-(1,3-dioxolan-2-yl)-4,5-dimethoxybenzaldehyde 
• 103477-58-3 2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane 
• 577-68-4 m-hemipinic acid 

Downstream Products

• 1509117-44-5 (2E,2'E)-3,3'-(4,5-dimethoxy-1,2-phenylene)bis(1-phenylprop-2-en-1-one) 

Relevant articles and documents

Enantioselective Iridium-Catalyzed Phthalide Formation through Internal Redox Allylation of Phthalaldehydes

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Traceless and Chemoselective Amine Bioconjugation via Phthalimidine Formation in Native Protein Modification

ortho-Phthalaldehyde (OPA) and its derivatives are found to react chemoselectively with amino groups on peptides and proteins rapidly and tracelessly under the physiological condition via formation of phthalimidines, which provides a novel and promising approach when performing bioconjugation on native proteins. The notable advantages of this method over the existing native protein lysine-labeling approaches include a traceless process, a self-reacting, specific and fast reaction, ease of operation, and the ability to use nonhydrolyzable reagents. Its applications have been effectively demonstrated including conjugation of peptides and proteins, and generation of an active PEGlyated l-asparaginase.

Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action

Water-soluble isoindoloquinoxalin (IIQ) imines and the corresponding acetates were conveniently prepared from the key intermediates 2-(2′-aminophenyl)-2H-isoindole-1-carbonitriles obtained by a Strecker reaction between substituted 1,2-dicarbaldehydes and 1,2-phenylenediamines. Both series were screened by the National Cancer Institute (Bethesda, MD) and showed potent antiproliferative activity against a panel of 60 human tumor cell lines. Several of the novel compounds showed GI50 values at a nanomolar level on the majority of the tested cell lines. Among IIQ derivatives, methoxy substituents at positions 3 and 8 or/and 9 were especially effective in impairing cell cycle progression and inducing apoptosis in cancer cells. These effects were associated to IIQ-mediated impairment of tubulin polymerization at pharmacologically significant concentrations of tested compounds. In addition, impaired DNA topoisomerase I functions and perturbation in telomere architecture were observed in cells exposed to micromolar concentrations of IIQ derivatives. The above results suggest that IIQ derivatives exhibit multi-target cytotoxic activities.