431-23-2

Basic information

• Product Name: 3,3,3-Trifluoro-2-Methylpropan-1-ol
• Synonyms: 3,3,3-Trifluoro-2-Methylpropan-1-ol
• CAS NO: 431-23-2
• Molecular Formula: C4H7F3O
• Molecular Weight: 128.0929896
• Mol File: 431-23-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 104.047°C at 760 mmHg
• Flash Point: 54.35°C
• Appearance: /
• Density: 1.177g/cm³
• Vapor Pressure: 17.289mmHg at 25°C
• Refractive Index: 1.335
• Storage Temp.: 2-8°C
• PKA: 14.24±0.10(Predicted)
• CAS DataBase Reference: 3,3,3-Trifluoro-2-Methylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,3-Trifluoro-2-Methylpropan-1-ol(431-23-2)
• EPA Substance Registry System: 3,3,3-Trifluoro-2-Methylpropan-1-ol(431-23-2)

Safety Data

• RIDADR: 1993
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 431-23-2(Hazardous Substances Data)

Usage

General Description

3,3,3-Trifluoro-2-Methylpropan-1-ol is a chemical compound with the molecular formula C4H7F3O. It is a colorless liquid with a strong odor, and it is commonly used as a solvent or intermediate in organic synthesis. This chemical is highly flammable and should be handled with care. It is also considered to be harmful if inhaled, ingested, or if it comes into contact with the skin. Additionally, it may cause irritation to the respiratory system and eyes. Overall, 3,3,3-Trifluoro-2-Methylpropan-1-ol is a versatile chemical with multiple applications but should be used with caution due to its potential hazards.

InChI:InChI=1/C4H7F3O/c1-3(2-8)4(5,6)7/h3,8H,2H2,1H3

Upstream product

• 381-97-5 (2RS)-3,3,3-trifluoro-2-methylpropanoic acid 
• 2794-71-0 3,3,3-trifluoro-2-methylpropan-1-amine hydrochloride 
• 2314-97-8 iodotrifluoromethane 
• 5689-83-8 4-methyl-[1,3,2]dioxathiolane 2,2-dioxide 
• 339-17-3 2-(trifluoromethyl)propionic acid methyl ester 

Relevant articles and documents

PHENYL SUBSTITUTED PYRAZOLES AS MODULATORS OF RORgT

The present invention comprises compounds of Formula I. wherein: R1, R3, R4, R5, R6, R7, R8, and Q are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Novel Nucleophilic Trifluoromethylation of Vicinal Diol Cyclic Sulfates

(Matrix Presented) A novel method for highly regioselective and stereospecific nucleophilic trifluoromethylation of vicinal diol cyclic sulfates, using the reagent derived from reduction of trifluoromethyl iodide by tetrakis(dimethylamino)ethylene (TDAE), is presented.