432015-86-6

Basic information

• Product Name: methyl 4-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-6-methyl-2-thio-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS NO: 432015-86-6
• Molecular Weight: 422.483
• Mol File: 432015-86-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-6-methyl-2-thio-1,2,3,4-tetrahydropyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-6-methyl-2-thio-1,2,3,4-tetrahydropyrimidine-5-carboxylate(432015-86-6)
• EPA Substance Registry System: methyl 4-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-6-methyl-2-thio-1,2,3,4-tetrahydropyrimidine-5-carboxylate(432015-86-6)

Safety Data

• Hazardous Substances Data: 432015-86-6(Hazardous Substances Data)

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 17356-08-0 thiourea 
• 36640-40-1 3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 

Relevant articles and documents

Novel dihydropyrimidines as a potential new class of antitubercular agents

A small library of 30 dihydropyrimidines was synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H 37Rv. Two compounds, ethyl 4-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol- 4-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5 carboxylate 4a and ethyl 4-[3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-oxo-1,2,3, 4-tetrahydropyrimidine-5-carboxylate 4d were found to be the most active compounds in vitro with MIC of 0.02 μg/mL against MTB and were more potent than isoniazid.