432037-43-9

Basic information

• Product Name: Butanedioic, 1-(chloromethyl)-4-t-butyl ester
• Synonyms: Butanedioic, 1-(chloromethyl)-4-t-butyl ester;Butanedioic acid 1-chloromethyl 4-tert-butyl ester;Chloromethyl tert-butyl succinate;CL208
• CAS NO: 432037-43-9
• Molecular Formula: C₉H₁₅ClO₄
• Molecular Weight: 222.67
• Mol File: 432037-43-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 255 ºC
• Flash Point: 93 ºC
• Appearance: /
• Density: 1.139
• Vapor Pressure: 0.0169mmHg at 25°C
• Refractive Index: 1.445
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Butanedioic, 1-(chloromethyl)-4-t-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanedioic, 1-(chloromethyl)-4-t-butyl ester(432037-43-9)
• EPA Substance Registry System: Butanedioic, 1-(chloromethyl)-4-t-butyl ester(432037-43-9)

Safety Data

• Hazardous Substances Data: 432037-43-9(Hazardous Substances Data)

Usage

General Description

Butanedioic, 1-(chloromethyl)-4-t-butyl ester, also known as di-tert-butyl malonate, is a chemical compound used in various industrial and research applications. It is a clear, colorless liquid that is insoluble in water and has a sweet, fruity odor. Butanedioic, 1-(chloromethyl)-4-t-butyl ester is commonly used as a reagent in organic synthesis to produce various other compounds, such as pharmaceuticals, agrochemicals, and polymers. It is also used as a solvent and as an intermediate in the production of other chemicals. Additionally, di-tert-butyl malonate is considered to be relatively stable and relatively non-toxic, but it should still be handled with care and proper safety procedures should be followed when working with it.

InChI:InChI=1/C9H15ClO4/c1-9(2,3)14-8(12)5-4-7(11)13-6-10/h4-6H2,1-3H3

Upstream product

• 15026-17-2 succinic acid mono-tert-butyl ester 
• 49715-04-0 chlorosulfuric acid chloromethyl ester 

Downstream Products

• 432037-76-8 1-[3-(tert-butoxycarbonyl)-propionyloxymethyl]-4-[N'-cyano-N-(6-(4-chlorophenoxy)-hexyl)-N-guanidino]-pyridinium chloride 

Relevant articles and documents

PYRAZOLE DERIVATIVES FOR CONTROLLING ARTHROPODS

The present invention relates to novel halogen-substituted compounds, to processes for their preparation and to their use for controlling animal pests, in particular arthropods and especially insects and arachnids.

Design and synthesis of rosiglitazone-ferulic acid-nitric oxide donor trihybrids for improving glucose tolerance

Glucose intolerance is associated with metabolic syndrome and type 2 diabetes mellitus (T2DM) while some new therapeutic drugs, such as rosiglitazone (Rosi), for T2DM can cause severe cardiovascular side effects. Herein we report the synthesis of Rosi-ferulic acid (FA)-nitric oxide (NO) donor trihybrids to improve glucose tolerance and minimize the side effects. In comparison with Rosi, the most active compound 21 exhibited better effects on improving glucose tolerance, which was associated with its NO production, antioxidant and anti-inflammatory activities. Furthermore, 21 displayed relatively high stability in the simulated gastrointestinal environments and human liver microsomes, and released Rosi in plasma. More importantly, 21, unlike Rosi, had little stimulatory effect on the membrane translocation of aquaporin-2 (AQP2) in kidney collecting duct epithelial cells. These, together with a better safety profile, suggest that the trihybrids, like 21, may be promising candidates for intervention of glucose intolerance-related metabolic syndrome and T2DM.

Cyanoguanidine prodrugs

The invention relates to compounds of the formula I wherein X1 and X2 independently represent a bond; a straight, branched and/or cyclic hydrocarbon diradical, optionally substituted with one or more hydroxy, halogen, nitro, amino, cyano, aminosulfonyl, alkylsulfonylamino, alkylcarbonyl, formyl, aminocarbonyl or alkylcarbonylamino; a heteroarylene or non-aromatic heterocyclic hydrocarbon diradical, all of which are optionally substituted with one or more straight, branched and/or cyclic non-aromatic hydrocarbon radical, hydroxyl, halogen, amino, nitro, cyano, aminosulfonyl, alkylsulfonylamino, alkylcarbonyl, formyl, aminocarbonyl or alkylcarbonylamino; Y1 and Y2 independently represent a bond, an ether diradical (R′—O—R″), an amine diradical (R′—N—R″), O, S, S(O), S(O)2, C(O), NH—CO, CO—NH, SO2—N(R′), methylene or N(R′)—SO2 wherein R′ and R″ independently represent straight or branched hydrocarbon diradicals containing up to 4 carbon atoms; Y3 represents O, O—C(O), C(O)—O, N(R8), R8 being hydrogen or C1-4alkyl R1 represents hydrogen or straight, branched and/or cyclic alkyl, optionally substituted with phenyl; or an aromatic hydrocarbon radical; R2 represents aryl, heteroaryl or a non-aromatic heterocyclic hydrocarbon radical, all of which are optionally substituted; tetrahydropyranyloxy, di-(C1-4 alkoxy)phosphinoyloxy or C1-4 alkoxycarbonylamino; R3 represents hydrogen; a straight, branched and/or cyclic hydrocarbon radical, optionally substituted with one or more amino, hydroxy, carboxy, halogen, nitro, cyano, alkoxy, aminocarbonyl, C1-4alkoxycarbonyl, C1-4alkoxycarbonylamino, sulfo, hydroxysulfonyloxy, dihydroxyphosphinoyloxy, phosphono, sulfamino, aminosulfonyl, aminoacylamino or dialkoxyphosphinoyl; heteroaryl or a non-aromatic heterocyclic hydrocarbon radical, all of which are optionally substituted with one or more straight, branched and/or cyclic hydrocarbon radical, amino, hydroxy, carboxy, halogen, nitro, cyano, alkoxy, aminocarbonyl, C1-4alkoxycarbonyl, C1-4alkoxycarbonylamino, sulfo, hydroxysulfonyloxy, dihydroxyphosphinoyloxy, phosphono, sulfamino, aminosulfonyl, aminoacylamino or dialkoxyphosphinoyl; wherein s is an integer from 1 to 200; R6 is hydrogen or an optionally substituted non-aromatic hydrocarbon radical; R7 is independently hydrogen or methyl; R4 and R5 independently represent hydrogen; a straight, branched and/or cyclic hydrocarbon radical, optionally substituted with halogen, hydroxyl, halogen, amino, nitro or cyano; A represents hydrogen, an optionally substituted, straight, branched and/or cyclic hydrocarbon radical, hydroxy, halogen, nitro, cyano, heteroaryl, heteroaralkyl or thiol; m and r are independently integers from 0 to 4; and n is 0 or 1; Z? is a pharmaceutically acceptable anion, such as chloride, bromide, iodide, sulfate, methanesulfonate, p-toluenesulfonate, nitrate or phosphate. The compounds are well suited as prodrugs in human and veterinary therapy.