4330-22-7

Basic information

• Product Name: 2,4-DIMETHOXY-5-FLUOROPYRIMIDINE
• Synonyms: 2,4-DIMETHOXY-5-FLUOROPYRIMIDINE;5-Fluoro-2,4-dimethoxypyrimidine
• CAS NO: 4330-22-7
• Molecular Formula: C₆H₇FN₂O₂
• Molecular Weight: 158.13
• Mol File: 4330-22-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 252.9 °C at 760 mmHg
• Flash Point: 106.8 °C
• Appearance: /
• Density: 1.234 g/cm³
• Vapor Pressure: 0.03mmHg at 25°C
• Refractive Index: 1.47
• CAS DataBase Reference: 2,4-DIMETHOXY-5-FLUOROPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHOXY-5-FLUOROPYRIMIDINE(4330-22-7)
• EPA Substance Registry System: 2,4-DIMETHOXY-5-FLUOROPYRIMIDINE(4330-22-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 4330-22-7(Hazardous Substances Data)

Usage

General Description

2,4-Dimethoxy-5-fluoropyrimidine is a specialized chemical compound typically used in chemistry labs for a variety of applications. It belongs to the chemical class of Pyrimidines, which consists of heterocyclic aromatic compounds similar to pyridine. However, it's uniquely characterized by the presence of methoxy and fluorine substituents in its molecular structure. The literature on this chemical often relates to its role in synthetic chemistry reactions, particularly in the area of drug synthesis and pharmaceutical chemistry. Its exact health effects, chemical stability, and environmental impacts may not be comprehensively documented, thus proper care and handling are encouraged when in use.

InChI:InChI=1/C6H7FN2O2/c1-10-5-4(7)3-8-6(9-5)11-2/h3H,1-2H3

Upstream product

• 77-78-1 dimethyl sulfate 
• 123551-51-9 5,5'-Mercuri-bis-(2,4-dimethoxypyrimidine) 

Downstream Products

• 2927-71-1 2,4-dichloro-5-fluoropyrimidine 
• 1480-96-2 2-methoxy-5-fluorouracil 
• 51-21-8 5-fluorouracil 
• 80504-48-9 1,2-dihydro-5-fluoro-4-methoxy-2-oxo-1-(2'-benzoyloxyethoxymethyl)pyrimidine 

Relevant articles and documents

Method for preparing 2,4-dichloro-5-fluoropyrimidine through ultraviolet photocatalytic reaction

The invention relates to a method for preparing 2,4-dichloro-5-fluoropyrimidine through an ultraviolet photocatalytic reaction. The problem of environmental pollution caused by preparation and waste acid treatment of 2,4-dichloro-5-fluoropyrimidine can be effectively solved. The method comprises the steps that 2,4-dimethoxy-5-fluoropyrimidine is dissolved in a solvent the weight volume of which is10-20 times that of the 2,4-dimethoxy-5-fluoropyrimidine, wherein according to the weight volume, the unit of solids is gram, and the unit of liquid is milliliter; a catalyst sulfuryl chloride is added, and the addition amount of the catalyst sulfuryl chloride is 2-5% of the mass of the 2,4-dichloro-5-fluoropyrimidine; after ultraviolet light irradiation is conducted for 10 minutes, chlorine gasis introduced, the reaction temperature is 15-30 DEG C, and stirring while chlorine introduction is conducted for 12 hours; an equal volume of ice water is added, liquid separation is conducted, an organic phase is washed with an aqueous sodium carbonate solution with the mass concentration of 5%, and water washing, drying and concentration under reduced pressure are conducted to form the solid product 2,4-dichloro-5-fluoropyrimidine. The preparation method is simple, easy to operate, low in cost and free of waste residues, effectively prevents environmental pollution and has significant economic and social benefits.