433267-55-1

Basic information

• Product Name: ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE
• Synonyms: ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE;RARECHEM AL BI 1264;1H-Pyrrole-2-carboxylic acid, 4-broMo-, ethyl ester;4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester;Ethyl 4-bromopyrrole-2-carboxylate;Ethyl 4-bromopyrrole-2-carboxylate 97%;EOS-60603
• CAS NO: 433267-55-1
• Molecular Formula: C₇H₈BrNO₂
• Molecular Weight: 218.05
• Mol File: 433267-55-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 58-63°C
• Boiling Point: 301.7 °C at 760 mmHg
• Flash Point: 136.3 °C
• Appearance: /
• Density: 1.576±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 13.58±0.50(Predicted)
• CAS DataBase Reference: ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE(433267-55-1)
• EPA Substance Registry System: ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE(433267-55-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 433267-55-1(Hazardous Substances Data)

Usage

General Description

Ethyl 4-bromo-1H-pyrrole-2-carboxylate is a chemical compound with the molecular formula C7H7BrNO2. It is a pyrrole derivative that contains a carboxylate and bromo functional group. Ethyl 4-bromo-1H-pyrrole-2-carboxylate is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and other organic molecules. It is also used as an intermediate in the synthesis of pyrrole-based drugs and agrochemicals. Ethyl 4-bromo-1H-pyrrole-2-carboxylate is a valuable compound in the field of medicinal chemistry and organic synthesis for the development of new chemical entities with potential therapeutic applications.

InChI:InChI=1/C7H8BrNO2/c1-2-11-7(10)6-3-5(8)4-9-6/h3-4,9H,2H2,1H3

Upstream product

• 72652-32-5 1-(4-bromo-1H-pyrrol-2-yl)-2,2,2-trichloroethanone 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 516465-80-8 4-bromo-1H-pyrrole-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester 

Downstream Products

• 1271022-90-2 BMS-911543 
• 516465-78-4 ethyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate 
• 259792-69-3 4-bromo-1H-pyrrole-2-carboxylic acid hydrazide 

Relevant articles and documents

Structural Optimizations of Thieno[3,2-b]pyrrole Derivatives for the Development of Metabolically Stable Inhibitors of Chikungunya Virus

Chikungunya virus (CHIKV) is a re-emerging vector-borne alphavirus, and there is no approved effective antiviral treatment currently available for CHIKV. We previously reported the discovery of thieno[3,2-b]pyrrole 1b that displayed good antiviral activit

Ni-Catalyzed C-H Functionalization in the Formation of a Complex Heterocycle: Synthesis of the Potent JAK2 Inhibitor BMS-911543

BMS-911543 is a complex pyrrolopyridine investigated as a potential treatment for myeloproliferative disorders. The development of a short and efficient synthesis of this molecule is described. During the course of our studies, a Ni-mediated C-N bond formation was invented, which enabled the rapid construction of the highly substituted 2-aminopyridine core. The synthesis of this complex, nitrogen-rich heterocycle was accomplished in only eight steps starting from readily available materials.

Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists

The synthesis and biological testing of novel classes of potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone and pyrrolopiperazinone scaffolds are described.