434-42-4

Basic information

• Product Name: (1-Bromo-2,2,2-trifluoroethyl)benzene
• Synonyms: (1-Bromo-2,2,2-trifluoroethyl)benzene;alpha-Bromo-alpha-(trifluoromethyl)toluene, 2-Bromo-2-phenyl-1,1,1-trifluoroethane;(1-Bromotrifluoroethyl)benzene;(1-Bromo-2,2,2-trifluoroethyl)benzene 95%
• CAS NO: 434-42-4
• Molecular Formula: C₈H₆BrF₃
• Molecular Weight: 239.0324496
• Mol File: 434-42-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 49 °C(Press: 5 Torr)
• Flash Point: 73℃
• Appearance: /
• Density: 1.555 g/mL at 25 °C
• Refractive Index: n20/D1.487
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (1-Bromo-2,2,2-trifluoroethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Bromo-2,2,2-trifluoroethyl)benzene(434-42-4)
• EPA Substance Registry System: (1-Bromo-2,2,2-trifluoroethyl)benzene(434-42-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 434-42-4(Hazardous Substances Data)

Usage

General Description

(1-Bromo-2,2,2-trifluoroethyl)benzene is an organic compound with the chemical formula C8H6BrF3. It is a colorless liquid with a strong, sweet odor, and is primarily used as a solvent in various industrial processes, such as pharmaceutical and agrochemical manufacturing. The compound is flammable and has a relatively high vapor pressure, making it important to handle with caution. It is also considered to be toxic to aquatic organisms and may cause long-term adverse effects in the environment. (1-Bromo-2,2,2-trifluoroethyl)benzene is a halogenated hydrocarbon, meaning it contains both bromine and fluorine atoms, which give it unique chemical properties and make it useful in certain chemical reactions and processes.

Upstream product

• 13652-13-6 toluene-4-sulfonic acid 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 21249-93-4 (2,2,2-trifluoroethyl)benzene 
• 340-04-5 1-phenyl-2,2,2-trifluoromethylethanol 

Downstream Products

• 56539-85-6 α-(trifluoromethyl)-phenylacetic acid 
• 147920-40-9 (1-fluoro-2-phenylvinyl)(phenyl)sulfide 

Relevant articles and documents

Synthesis of Chiral α-CF3-Substituted Benzhydryls via Cross-Coupling Reaction of Aryltitanates

We describe a highly efficient approach toward α-CF3-substituted benzhydryls thanks to the employment of organotitanium(IV) based nucleophiles. The use of commercially available anesthetic halothane as a cheap fluorinated building block in a sequential one-pot nickel-catalyzed enantioselective cross-coupling reaction of aryl titanates allowed for the synthesis of chiral α-CF3-substituted benzhydryls in good yields and excellent enantioselectivities. Alternatively, α-CF3-benzyl bromides could be employed under similar conditions to obtain the same family of compounds in higher yields and excellent selectivities. A benzhydryl moiety is a common motif in many biologically active compounds, and their enantioenriched fluorinated analogs should be of great interest in the search for novel drugs and agrochemicals.

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