4342-08-9

Basic information

• Product Name: 5-AMINO-1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE
• Synonyms: 1H-[1,2,3]Triazole-4-carboxamide, 5-amino-1-(phenylmethyl)-;5-AMINO-1-BENZYL-1,2,3-TRIAZOLE-4-CARBOXAMIDE;5-AMINO-1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE;5-AMINO-1-BENZYL-1H-[1,2,3]-TRIAZOLE-4-CARBOXYLIC ACID AMIDE;BUTTPARK 131\40-98;TOSLAB 5425;TIMTEC-BB SBB000568;5-amino-1-(benzyl)triazole-4-carboxamide
• CAS NO: 4342-08-9
• Molecular Formula: C₁₀H₁₁N₅O
• Molecular Weight: 217.23
• Mol File: 4342-08-9.mol
• Article Data: 19

Chemical Properties

• Melting Point: 236°
• Boiling Point: 492°Cat760mmHg
• Flash Point: 251.4°C
• Appearance: /
• Density: 1.47g/cm³
• Vapor Pressure: 7.97E-10mmHg at 25°C
• Refractive Index: 1.719
• PKA: 14.35±0.50(Predicted)
• CAS DataBase Reference: 5-AMINO-1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE(4342-08-9)
• EPA Substance Registry System: 5-AMINO-1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE(4342-08-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 4342-08-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 5832, 1956 DOI: 10.1021/ja01603a033

InChI:InChI=1/C10H11N5O/c11-9-8(10(12)16)13-14-15(9)6-7-4-2-1-3-5-7/h1-5H,6,11H2,(H2,12,16)

Upstream product

• 21323-77-3 3-benzyl-4-methylamino-1,2,3-triazole-5-carboxamide 
• 107-91-5 cyanoacetic acid amide 
• 100-44-7 benzyl chloride 
• 79248-12-7 3-benzyl-4-methyamino-1,2,3-triazole-5-carbonitrile 
• 622-79-7 benzyl azide 
• 20271-33-4 1-benzyl-5-amino-1,2,3-triazole-4-carboxylic acid ethyl ester 
• 3815-67-6 2-Carbamoyl-N-benzylacetamidine hydrochloride 
• 100-39-0 benzyl bromide 
• 55898-94-7 3-benzyl-4-formamido-1,2,3-triazole-5-carbonitrile 
• 79248-01-4 bis-(3-benzyl-4-N-methylamino-1,2,3-triazole-5-carbonyl)-amine 
• 79248-00-3 3-benzyl-4-N-methylformamido-1,2,3-triazole-5-carboxamide 
• 79248-11-6 3-benzyl-4-N-methylformamido-1,2,3-triazole-5-carbonitrile 
• 79248-02-5 9-benzyl-3-methyl-8-azapurin-6(3H)-one 

Downstream Products

• 105202-61-7 3-benzyl-5-phenyl-3,6-dihydro-1,2,3-triazolo[4,5-d]pyrimidin-7-one 
• 105202-63-9 N-(3-Benzyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylmethyl)-benzamide 
• 71492-05-2 9-benzyl-2-methyl-8-azapurin-6-one 
• 105202-57-1 3-Benzyl-5-ethoxymethyl-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 105202-55-9 3-Benzyl-5-ethyl-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 105202-56-0 3-Benzyl-5-propyl-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 105202-62-8 3,5-Dibenzyl-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 105202-60-6 3-Benzyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-carboxylic acid ethyl ester 
• 105202-58-2 3-Benzyl-5-diethoxymethyl-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 21324-31-2 3-Benzyl-7-hydroxy-3H-1,2,3-triazolo<4,5-d>pyrimidine 
• 105202-59-3 3-(3-Benzyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)-propionic acid 
• 20271-35-6 5-amino-1-benzyl-1H-[1,2,3]triazole-4-carbonitrile 
• 103912-77-2 5-azido-1-benzyl-4-carbamoyl-1,2,3-triazole 
• 156120-38-6 2-n-butyl-9-benzyl-8-azahypoxanthine 

Relevant articles and documents

Cytoprotective activities of kinetin purine isosteres

Kinetin (N6-furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal models. Here we report the synthesis of kinetin isosteres with the purine ring replace

Water/Alkali-Catalyzed Reactions of Azides with 2-Cyanothioacetamides. Eco-Friendly Synthesis of Monocyclic and Bicyclic 1,2,3-Thiadiazole-4-carbimidamides and 5-Amino-1,2,3-triazole-4-carbothioamides

The reactions of thioamides with azides in water were studied. It was reliably shown that the reaction of 2-cyanothioacetamides 1 with various types of azides 2 in water in the presence of alkali presents an efficient, general, one-step, atom-economic, and eco-friendly method for the synthesis of 1,2,3-thiadiazol-4-carbimidamides 5 and 1,2,3-triazole-4-carbothioamides 4. This method can be extended to the one-pot reaction of sulfonyl chlorides and 6-chloropyrimidines 2′o with sodium azide, leading to final products in higher yields, that is, avoiding the isolation of unsafe sulfonyl azides. The method was furthermore applied to the reaction of N,N′-bis-(2-cyanothiocarbonyl)pyrazine 1h with sulfonyl azides to afford bicyclic 1,2,3-thiadiazoles 8 and 1,2,3-triazoles 9 connected via a 1,1′-piperazinyl linker. 2-Cyanothioacetamides 1 were also shown to react with aromatic azides in water in the presence of alkali to afford 1-aryl-5-amino-1,2,3-triazole-4-carbothioamides 11. In contrast to aromatic azides and similarly to sulfonyl azides, 6-azidopyrimidine-2,4-diones 2o-q react with cyanothioacetamides to form N-pyrimidin-6-yl-5-dialkylamino-1,2,3-thiadiazole-4-N-l-carbimidamides 12. A mechanism was proposed to rationalize the role of water in changing the reactivity of azides toward 2-cyanothioacetamides.

NEW TRPA1 ANTAGONISTS

The present invention relates to bicyclic heterocyclic derivatives of Forrmula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.