435345-05-4

Basic information

• Product Name: (3-Chloro-2-oxo-2H-pyrazin-1-yl)-acetic acid ethyl ester
• Synonyms: (3-Chloro-2-oxo-2H-pyrazin-1-yl)-acetic acid ethyl ester;1(2H)-Pyrazineacetic acid, 3-chloro-2-oxo-, ethyl ester;Ethyl 2-(6-chloro-5-oxo-4,5-dihydropyrazin-2-yl)acetate;3-chloro-2-oxo-1(2H)-Pyrazineacetic acid Ethyl ester
• CAS NO: 435345-05-4
• Molecular Formula: C₈H₉ClN₂O₃
• Molecular Weight: 216.62166
• Mol File: 435345-05-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 313.245 °C at 760 mmHg
• Flash Point: 143.246 °C
• Appearance: /
• Density: 1.372 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (3-Chloro-2-oxo-2H-pyrazin-1-yl)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Chloro-2-oxo-2H-pyrazin-1-yl)-acetic acid ethyl ester(435345-05-4)
• EPA Substance Registry System: (3-Chloro-2-oxo-2H-pyrazin-1-yl)-acetic acid ethyl ester(435345-05-4)

Safety Data

• Hazardous Substances Data: 435345-05-4(Hazardous Substances Data)

Usage

General Description

(3-Chloro-2-oxo-2H-pyrazin-1-yl)-acetic acid ethyl ester is a chemical compound with the molecular formula C7H7ClN2O3. It is an ethyl ester derivative of (3-Chloro-2-oxo-2H-pyrazin-1-yl)-acetic acid, which is a pyrazine derivative. (3-Chloro-2-oxo-2H-pyrazin-1-yl)-acetic acid ethyl ester is commonly used in organic synthesis and chemical research as a building block for various pharmaceutical and agrochemical products. It is also used as an intermediate in the production of other chemical compounds and as a reagent in chemical reactions. Additionally, it has potential applications in the development of new drugs and crop protection products due to its versatile chemical structure and properties. However, it is important to handle this compound with care due to its potentially hazardous nature.

InChI:InChI=1/C8H9ClN2O3/c1-2-14-6(12)5-11-4-3-10-7(9)8(11)13/h3-4H,2,5H2,1H3

Upstream product

• 29655-79-6 [(2-ethoxy-2-oxoethyl)amino]oxoacetic acid ethyl ester 
• 312904-86-2 N-(ethylcarboxymethyl)-N'-(2,2-dimethoxyethyl)oxamide 
• 105-36-2 ethyl bromoacetate 
• 312904-87-3 ethyl 3-hydroxypyrazin-(1H)-2-one-1-acetate 

Downstream Products

• 1207283-03-1 [3-(2,2-difluoro-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]acetic acid ethyl ester 
• 1026348-21-9 2-{3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)-ethylamino]-2-oxo-2H-pyrazin-1-yl}-N-(2-fluoro-benzyl)-acetamide 
• 342815-51-4 N-2-fluorobenzyl [3-(2,2-difluoro-2-(2-pyridyl-N-oxide)ethylN-amino)-6-chloro-2-oxo-2H-pyrazin-1-yl]acetamide 

Relevant articles and documents

MASP-2 INHIBITORS AND METHODS OF USE

The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.

Synthesis of 3-Aminopyrazinone Mediated by 2-Pyridylthioimidate-ZnCl 2 Complexes. Development of an Efficient Route to a Thrombin Inhibitor

A six-step preparation of thrombin inhibitor drug candidate 1 from pyrazinone 7 in 47% overall yield is described. The problem of low reactivity between weak amine nucleophile 4 and poor electrophile 3-bromopyrazinone 17 was overcome with the use of pyrid