4357-60-2

Basic information

• Product Name: N-(2-BROMOPHENYL)ANTHRANILIC ACID
• Synonyms: N-(2-BROMOPHENYL)ANTHRANILIC ACID
• CAS NO: 4357-60-2
• Molecular Formula: C₁₃H₁₀BrNO₂
• Molecular Weight: 292.13
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 4357-60-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-BROMOPHENYL)ANTHRANILIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-BROMOPHENYL)ANTHRANILIC ACID(4357-60-2)
• EPA Substance Registry System: N-(2-BROMOPHENYL)ANTHRANILIC ACID(4357-60-2)

Safety Data

• Hazardous Substances Data: 4357-60-2(Hazardous Substances Data)

Upstream product

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• 134-20-3 2-carbomethoxyaniline 
• 610-94-6 2-bromobenzoic acid methyl ester 

Relevant articles and documents

Design, synthesis and bioactivity evaluation of novel N-phenyl-substituted evodiamine derivatives as potent anti-tumor agents

Natural products are important sources for the development of therapeutic medicine, among which evodia fruit has a wide range of medicinal properties in traditional Chinese medicine. Evodiamine, the main active component of evodia fruit, has various anti-cancer effects and has been proved to be a Topo inhibitor. From our previous attempts of modifying evodiamine, we found that the N14 phenyl substituted derivatives had showed great anti-tumor activity, which prompted us to further explore the novel structures and activities of these compounds. Compound 6f, as a N14 3-fluorinated phenyl substituted evodiamine derivative, showed a certain inhibitory activity against Topo I at 200 μM. By studying its anti-tumor effects in vitro, compound 6f could inhibit proliferation and induce apoptosis, as well as arrest the cell cycle of HGC-27 and HT-29 cell lines at G2/M phase in a concentration-dependent manner. Moreover, compound 6f could inhibit the migration and invasion of HGC-27 cell lines. Meanwhile, compound 6f could induce apoptosis of HGC-27 cells by inhibiting PI3K/AKT pathway. Overall, this work demonstrated that the N14 phenyl-substituted evodiamine derivatives had a good inhibitory effect on tumor cells in vitro, providing a promising strategy for developing potential anticancer agents for the treatment of gastrointestinal tumors.

Polycyclic aromatic compound and application thereof in electroluminescent device

The invention relates to a polycyclic aromatic compound and application thereof. The compound has a structure as shown in a formula I which is described in the specification. When the compound provided by the invention is used as a luminescent layer mater