4370-90-5

Basic information

• Product Name: PTH-METHIONINE
• Synonyms: 5-(2-(methylthio)ethyl)-3-phenyl-2-thioxo-4-imidazolidinon;5-(2-methylthioethyl)-3-phenyl-2-thio-hydantoi;methioninephenylthiohydantoin;methionylphenylthiohydantoin;5-[2-(METHYLTHIO)ETHYL]-3-PHENYL-2-THIOHYDANTOIN;PTH-DL-METHIONINE;PTH-METHIONINE;PHENYLTHIOHYDANTOIN-METHIONINE
• CAS NO: 4370-90-5
• Molecular Formula: C₁₂H₁₄N₂OS₂
• Molecular Weight: 266.38
• EINECS: 224-464-0
• Product Categories: Amino Acids;Amino Acids (N-Protected);Biochemistry;PTH-Amino Acids;Protein Sequencing;Protein Structural Analysis;Reagents for Protein Sequencing
• Mol File: 4370-90-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 180°C
• Boiling Point: 384.2°Cat760mmHg
• Flash Point: 186.2°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 4.15E-06mmHg at 25°C
• Refractive Index: 1.671
• Storage Temp.: −20°C
• PKA: 10.85±0.40(Predicted)
• CAS DataBase Reference: PTH-METHIONINE(CAS DataBase Reference)
• NIST Chemistry Reference: PTH-METHIONINE(4370-90-5)
• EPA Substance Registry System: PTH-METHIONINE(4370-90-5)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• RTECS: MU2700000
• Hazardous Substances Data: 4370-90-5(Hazardous Substances Data)

Usage

General Description

PTH-methionine is a synthetic version of parathyroid hormone (PTH) that contains a modified form of the amino acid methionine. PTH-methionine acts as an agonist for the PTH receptor, promoting the release of calcium from bone, reabsorption of calcium in the kidneys, and activation of vitamin D in the kidneys, which ultimately increases serum calcium levels. This synthetic hormone is used in the treatment of hypoparathyroidism, a condition characterized by low levels of PTH, as it can effectively regulate calcium and phosphate metabolism in the body. PTH-methionine is administered through injection and is a valuable therapeutic option for managing conditions related to calcium regulation.

InChI:InChI=1/C12H14N2OS2/c1-17-8-7-10-11(15)14(12(16)13-10)9-5-3-2-4-6-9/h2-6,10H,7-8H2,1H3,(H,13,16)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 59-51-8 DL-methionine 

Downstream Products

• 1062634-87-0 [CuCl(5-[2-(methylthio)ethyl]-3-phenyl-2-thioxoimidazolidin-4-one(-1H))]2 

Relevant articles and documents

Enantioselective Synthesis of 5,5-Disubstituted Hydantoins by Br?nsted Base/H-Bond Catalyst Assisted Michael Reactions of a Design Template

A new method for the enantioselective synthesis of 5,5-disubstituted (quaternary) hydantoins was developed on the basis of an organocatalytic Michael reaction approach involving the use of 2-benzylthio-3,5-dihydroimidazol-4-ones as key hydantoin surrogates. The method is general with respect to the substitution pattern at the hydantoin N1 (alkyl, aryl, acyl), N3 (aryl), and C5 (linear/branched alkyl, aryl) positions and affords essentially single diastereomeric products with enantioselectivities higher than 95 % ee in most cases. Among the bifunctional Br?nsted base/H-bond catalysts examined, a known squaramide–tertiary amine catalyst and a newly prepared squaramide–tertiary amine catalyst provide the highest selectivity so far with either nitroolefins or vinyl ketones as the acceptor components. Kinetic measurements support a first-order rate dependence on both reaction partners, the donor template and the Michael acceptor, whereas competitive 1H NMR spectroscopy experiments reveal the high ability of the template for catalyst binding.