4375-03-5

Basic information

• Product Name: [1R,(-)]-1α,4β-Bis(3,4-dimethoxyphenyl)-3aα,4,6,6aα-tetrahydro-1H,3H-furo[3,4-c]furan
• Synonyms: [1R,(-)]-1α,4β-Bis(3,4-dimethoxyphenyl)-3aα,4,6,6aα-tetrahydro-1H,3H-furo[3,4-c]furan;Epieudesamin;Epieudesmin;Symplocosigenol dimethyl ether
• CAS NO: 4375-03-5
• Molecular Formula: C₂₂H₂₆O₆
• Molecular Weight: 386.43824
• Mol File: 4375-03-5.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [1R,(-)]-1α,4β-Bis(3,4-dimethoxyphenyl)-3aα,4,6,6aα-tetrahydro-1H,3H-furo[3,4-c]furan(CAS DataBase Reference)
• NIST Chemistry Reference: [1R,(-)]-1α,4β-Bis(3,4-dimethoxyphenyl)-3aα,4,6,6aα-tetrahydro-1H,3H-furo[3,4-c]furan(4375-03-5)
• EPA Substance Registry System: [1R,(-)]-1α,4β-Bis(3,4-dimethoxyphenyl)-3aα,4,6,6aα-tetrahydro-1H,3H-furo[3,4-c]furan(4375-03-5)

Safety Data

• Hazardous Substances Data: 4375-03-5(Hazardous Substances Data)

Upstream product

• 77-78-1 dimethyl sulfate 
• 32971-25-8 pinoresinol 
• 186581-53-3 diazomethane 
• 4263-88-1 pinoresinol 
• 7647-01-0 hydrogenchloride 
• 60102-89-8 (+)-epipinoresinol dimethyl ether 
• 10061-38-8 (-)-epipinoresinol 
• 526-06-7 eudesmine 
• 133-03-9 (-)-asarinin 
• 81446-29-9 (-)-pinoresinol 
• 487-36-5 (+/-)-pinoresinol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 340167-81-9 rel-(7α,7'α,8α,8'α)-7,9':7',9-diepoxylignane-3,3',4,4'-tetraol 
• 69854-19-9 2,6-bis-(3,4-dimethoxyphenyl)-3,7-dioxabicyclo<3.3.0>octane-4,8-dione 

Downstream Products

• 58311-18-5 (2R,3R)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-diol 
• 60102-89-8 (+)-epipinoresinol dimethyl ether 
• 20610-45-1 (3aR)-1c,4c-bis-(2-bromo-4,5-dimethoxy-phenyl)-(3ar,6ac)-tetrahydro-furo[3,4-c]furan 
• 20610-45-1 (+/-)-1c,4c-bis-(2-bromo-4,5-dimethoxy-phenyl)-(3ar,6ac)-tetrahydro-furo[3,4-c]furan 
• 20610-45-1 (3aS)-1c,4t-bis-(2-bromo-4,5-dimethoxy-phenyl)-(3ar,6ac)-tetrahydro-furo[3,4-c]furan 
• 20610-45-1 (3aS)-1c,4c-bis-(2-bromo-4,5-dimethoxy-phenyl)-(3ar,6ac)-tetrahydro-furo[3,4-c]furan 
• 81446-29-9 (-)-pinoresinol 
• 487-39-8 (+)-pinoresinol monomethyl ether 
• 3395-03-7 4,5-dimethoxy-1,2-dinitrobenzene 
• 93-07-2 Veratric acid 

Relevant articles and documents

Stereoselective total synthesis of furofuran lignans through dianion aldol condensation

Highly stereoselective total synthesis of (+)-eudesmin, (+)-yangambin, (-)-eudesmin, and (-)-yangambin is described. This method is useful to generate the core skeleton of furofuran rings utilizing modification of Evans asymmetric aldol condensation.

Sesquineolignans and other constituents from the seeds of Joannesia princeps

From the as extract of the seeds of the Brazilian Joannesia princeps 3,3′-bisdemethylpinoresinol and six new sesquineolignans were isolated besides the known neolignans americanol A, isoamericanol A and isoamericanin A which were found to be the major constituents. A method was developed to distinguish americanol- from isoamericanol-type compounds spectroscopically.

Stereoselective homocoupling of chiral 1-aroylacetyl-2-imidazolidinones by oxidation with Br2

The oxidative coupling of sodium enolates of (4R,5S)-1-aroylacetyl-3,4-dimethyl-5-phenyl-2-imidazolidinones with Br2 as the oxidant affords the R,R-dimers stereoselectively. The R,R-selectivity can be explained by a radical coupling mechanism.