437651-42-8

Basic information

• Product Name: methyl 4-(3-(dibutylamino)propoxy)benzoate
• Synonyms: methyl 4-(3-(dibutylamino)propoxy)benzoate;4-[3-(DibutylaMino)propoxy]benzoic Acid Methyl Ester
• CAS NO: 437651-42-8
• Molecular Formula: C19H31NO3
• Molecular Weight: 321.45434
• EINECS: -0
• Product Categories: API;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 437651-42-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 422.877 °C at 760 mmHg
• Flash Point: 209.549 °C
• Appearance: /
• Density: 0.993
• Storage Temp.: 2-8°C
• PKA: 9.45±0.50(Predicted)
• CAS DataBase Reference: methyl 4-(3-(dibutylamino)propoxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(3-(dibutylamino)propoxy)benzoate(437651-42-8)
• EPA Substance Registry System: methyl 4-(3-(dibutylamino)propoxy)benzoate(437651-42-8)

Safety Data

• Hazardous Substances Data: 437651-42-8(Hazardous Substances Data)

Usage

Uses

Dronedarone intermediate.

Upstream product

• 111-92-2 dibutylamine 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 109-64-8 1,3-dibromo-propane 
• 69076-29-5 4-(3-chloropropoxy)benzoic acid methyl ester 
• 36421-15-5 dibutyl-(3-chloro-propyl)-amine 

Relevant articles and documents

Method for synthesizing [...] reach silom

The invention discloses a dronedarone synthesis method. According to the method, 4-[3-(dibutylamino)propoxy]methyl benzoate, 4-[3-(dibutylamino)propoxy]benzoic acid hydrochloride, 4-[3-(dibutylamino)propoxy]benzoyl chloride, 2-bromohexanoyl chloride, p-methoxyacetanilide, 3-(2-bromohexanoyl chloride)-4-hydroxyacetanilide, N-2-butyl-5-benzofuranamine hydrochloride, N-[(2-butyl-2,3-2H-5-benzofuran)methanesulfonamide], N-2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuran]-methanesulfonamide and dronedarone are obtained through step-reactions. The dronedarone synthesis method is simple in process, convenient to operate and high in rate of production.

2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof

The invention relates to 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl-5-nitrobenzofuran hydrochloride, to its preparation and to its use as synthetic intermediate, in particular in preparing 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)-5-nitrobenzofuran, itself an intermediate for dronedarone.