4385-05-1

Basic information

• Product Name: 4-[2-(Dimethylamino)ethyl]morpholine
• Synonyms: 4-Morpholineethanamine, N,N-dimethyl-;N,N-Dimethyl-2-(4-morpholinyl)ethanamine;n,n-dimethyl-4-morpholineethanamin;N,N-Dimethyl-4-morpholineethanamine;4-[2-(DIMETHYLAMINO)ETHYL]MORPHOLINE;4-DIMETHYLAMINE ETHYLMORPHOLINE;4-(2-(DIMETHYLAMINO)ETHYL)MORPHOLINE 9&;N,N-Dimethylmorpholine-4-ethanamine
• CAS NO: 4385-05-1
• Molecular Formula: C₈H₁₈N₂O
• Molecular Weight: 158.24
• EINECS: 224-492-3
• Mol File: 4385-05-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 93-94 °C20 mm Hg(lit.)
• Flash Point: 168 °F
• Appearance: /
• Density: 0.925 g/mL at 25 °C(lit.)
• Vapor Pressure: 3 mm Hg ( 20 °C)
• Refractive Index: n20/D 1.4582(lit.)
• Storage Temp.: 2-8°C
• PKA: 9.41±0.28(Predicted)
• CAS DataBase Reference: 4-[2-(Dimethylamino)ethyl]morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(Dimethylamino)ethyl]morpholine(4385-05-1)
• EPA Substance Registry System: 4-[2-(Dimethylamino)ethyl]morpholine(4385-05-1)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 4385-05-1(Hazardous Substances Data)

Usage

General Description

4-[2-(Dimethylamino)ethyl]morpholine is a chemical compound with the molecular formula C10H21NO. It is a morpholine derivative with a dimethylaminoethyl substituent. 4-[2-(Dimethylamino)ethyl]morpholine is commonly used as a reagent in organic synthesis, particularly in the preparation of various pharmaceuticals and agrochemicals. It can also be used as a solvent in a variety of chemical reactions. 4-[2-(Dimethylamino)ethyl]morpholine is a colorless liquid with a strong amine odor, and it is considered to be a hazardous substance. It is important to handle and store this compound with care, as exposure to large amounts of 4-[2-(Dimethylamino)ethyl]morpholine can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C8H18N2O/c1-9(2)3-4-10-5-7-11-8-6-10/h3-8H2,1-2H3

Upstream product

• 74927-38-1 2,2'-diethylene glycol sulfonate 
• 108-00-9 N,N-dimethylethylenediamine 
• 123091-15-6 2-dimethylamino ethanol p-toluene sulfonate 
• 110-91-8 morpholine 
• 3240-94-6 N-(2-chlorethyl)morpholine 
• 124-40-3 dimethyl amine 
• 2038-03-1 4-(2-AMINOETHYL)MORPHOLINE 
• 67-56-1 methanol 

Relevant articles and documents

Preparation method of 4-(2-(N, N-dimethylamino)ethyl)morpholine

The invention discloses a preparation method of 4-(2-(N, N-dimethylamino)ethyl)morpholine in the technical field of organic synthesis chemical industry, which comprises the following steps: dissolving2, 2'-diethylene glycol sulfonate and N, N-dimethylethylenediamine used as initial raw materials in a solvent, and carrying out cyclization reaction in the presence of an acid-binding agent to prepare 4-(2-(N, N-dimethylamino)ethyl)morpholine, the acid-binding agent is one of triethylamine, sodium hydroxide, sodium bicarbonate, sodium carbonate and potassium carbonate, the solvent is one of dimethyl sulfoxide, N, N-dimethyl formamide, N, N-dimethyl acetamide and tetrahydrofuran, the reaction temperature is 60 DEG C to 80 DEG C, and the reaction time is 6-9 hours. The method is mild in reaction condition and simple to operate, and has good popularization and application values, the obtained target product has huge application value in the aspects of chemical pharmacy, pesticides, organic synthesis and the like.

Well-Defined Phosphine-Free Iron-Catalyzed N-Ethylation and N-Methylation of Amines with Ethanol and Methanol

An iron(0) complex bearing a cyclopentadienone ligand catalyzed N-methylation and N-ethylation of aryl and aliphatic amines with methanol or ethanol in mild and basic conditions through a hydrogen autotransfer borrowing process is reported. A broad range of aromatic and aliphatic amines underwent mono- or dimethylation in high yields. DFT calculations suggest molecular hydrogen acts not only as a reducing agent but also as an additive to displace thermodynamic equilibria.