4385-62-0

Basic information

• Product Name: 4-(2-Pyridyl)benzoic acid
• Synonyms: RARECHEM AL BE 0861;4-(PYRIDIN-2-YL)BENZOIC ACID;4-(2-PYRIDYL)BENZOIC ACID;4-(2-PYRIDINYL)BENZOIC ACID;AKOS BAR-0485;4-Pyridin-2-yl-benzoicacid95%;4-(3-Fluoropyridin-2-yl)benzoic acid;4-(4-Chloropyridin-2-yl)benoic acid
• CAS NO: 4385-62-0
• Molecular Formula: C₁₂H₉NO₂
• Molecular Weight: 199.21
• Product Categories: pharmacetical;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 4385-62-0.mol
• Article Data: 33

Chemical Properties

• Melting Point: 236.0 to 240.0 °C
• Boiling Point: 388.137 °C at 760 mmHg
• Flash Point: 188.539 °C
• Appearance: /
• Density: 1.241 g/cm³
• Vapor Pressure: 1.02E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 3.17±0.10(Predicted)
• CAS DataBase Reference: 4-(2-Pyridyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Pyridyl)benzoic acid(4385-62-0)
• EPA Substance Registry System: 4-(2-Pyridyl)benzoic acid(4385-62-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 4385-62-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 4385-62-0 differently. You can refer to the following data:
1. Reactive metabolite of Atazanavir (A790051).
2. Reactive metabolite of Atazanavir (A790051). Atazanavir Impurity (Pyridinyl Benzoic Acid)

InChI:InChI=1/C12H9NO2/c14-12(15)10-6-4-9(5-7-10)11-3-1-2-8-13-11/h1-8H,(H,14,15)/p-1

Upstream product

• 110-86-1 pyridine 
• 150-13-0 4-amino-benzoic acid 
• 5029-67-4 2-iodopyridine 
• 14047-29-1 4-carboxyphenylboronic acid 
• 40881-45-6 4-tolylboronic dimethyl ester 
• 127406-56-8 4-(2'-pyridyl)benzaldehyde 
• 5720-05-8 4-methylphenylboronic acid 
• 106-38-7 para-bromotoluene 
• 98061-21-3 4-pyridin-2-yl-benzoic acid methyl ester 
• 87199-17-5 4-formylphenylboronic acid, 
• 109-04-6 2-bromo-pyridine 
• 32111-34-5 4-(pyridine-2-yl)benzonitrile 
• 4467-06-5 2-(4-methylphenyl)pyridine 
• 18471-73-3 4-(pyridin-2-yl)aniline 

Downstream Products

• 223119-17-3 ethyl 2-ethoxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate 
• 874452-32-1 N-(4-hydroxybutyl)-4-(pyridin-2-yl)benzamide 
• 1354353-47-1 N-(4-(2-methylpyridin-4-yl)benzyl)-4-(pyridin-2-yl)benzamide 
• 190850-37-4 4-(pyridin-2-yl)benzoyl chloride 
• 1184950-40-0 4-benzyloxy-1-(2-oxo-2-{4-[1-(2,2,2-trifluoro-acetyl)-piperidin-2-yl]-phenyl}-ethyl)-1H-pyridin-2-one 
• 1184948-99-9 4-benzyloxy-1-[2-oxo-2-(4-piperidin-2-yl-phenyl)-ethyl]-1H-pyridin-2-one 
• 1184950-36-4 N-methoxy-N-methyl-4-[1-(2,2,2-trifluoro-acetyl)-piperidin-2-yl]-benzamide 
• 1184950-39-7 1-{2-[4-(2-bromo-acetyl)-phenyl]-piperidin-1-yl}-2,2,2-trifluoro-ethanone 

Relevant articles and documents

New cyclometalated iridium(III) dye chromophore complexes for p-type dye-sensitised solar cells

The synthesis of seven iridium complexes [Ir(C?N)2(N?N)][PF6] (AS9-15) designed as dyes for p-type DSSC is described. These complexes comprise a 4-(pyrid-2-yl)benzoic acid as the cyclometalating/anchoring ligand with different diimin

Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors

CBP bromodomain could recognize acetylated lysine and function as transcription coactivator to regulate transcription and downstream gene expression. Furthermore, CBP has been shown to be related to many human malignancies including acute myeloid leukemia. Herein, we identified DC-CPin734 as a potent CBP bromodomain inhibitor with a TR-FRET IC50 value of 19.5 ± 1.1 nM and over 400-fold of selectivity against BRD4 bromodomains through structure based rational drug design guided iterative chemical modification endeavoring to discover optimal tail-substituted tetrahydroquinolin derivatives. Moreover, DC-CPin734 showed potent inhibitory activity to AML cell line MV4-11 with an IC50 value of 0.55 ± 0.04 μM, and its cellular on-target effects were further evidenced by c-Myc downregulation results. In summary, DC-CPin734 showing good potency, selectivity and anti AML activity could serve as a potent and selective in vitro and in vivo probe of CBP bromodomain and a promising lead compound for future drug development.

Preparation method of pure water printing paper based on bimetallic complex

The invention discloses a preparation method of pure water printing paper. 4-(2-pyridyl)benzaldehyde is used as raw materials; an Ir-Eu bimetallic complex with humidity response characteristics is sequentially obtained through oxidization reaction, metal