439089-67-5

Basic information

• Product Name: (R)-1-(2,4-Dimethoxy-benzyl)-4-oxo-3-[3-(2,2,2-trifluoro-acetylamino)-propyl]-azetidine-2,2-dicarboxylic acid dimethyl ester
• Synonyms: (R)-1-(2,4-Dimethoxy-benzyl)-4-oxo-3-[3-(2,2,2-trifluoro-acetylamino)-propyl]-azetidine-2,2-dicarboxylic acid dimethyl ester
• CAS NO: 439089-67-5
• Molecular Weight: 490.433
• Mol File: 439089-67-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-1-(2,4-Dimethoxy-benzyl)-4-oxo-3-[3-(2,2,2-trifluoro-acetylamino)-propyl]-azetidine-2,2-dicarboxylic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(2,4-Dimethoxy-benzyl)-4-oxo-3-[3-(2,2,2-trifluoro-acetylamino)-propyl]-azetidine-2,2-dicarboxylic acid dimethyl ester(439089-67-5)
• EPA Substance Registry System: (R)-1-(2,4-Dimethoxy-benzyl)-4-oxo-3-[3-(2,2,2-trifluoro-acetylamino)-propyl]-azetidine-2,2-dicarboxylic acid dimethyl ester(439089-67-5)

Safety Data

• Hazardous Substances Data: 439089-67-5(Hazardous Substances Data)

Upstream product

• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 439089-64-2 (R)-2-Amino-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid 
• 439089-65-3 (R)-2-Bromo-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid 
• 439089-66-4 dimethyl N-(2,4-dimethoxybenzyl)aminomalonate 
• 16682-12-5 D-ornithine hydrochloride 

Relevant articles and documents

A stereoselective synthesis of BMS-262084, an azetidinone-based tryptase inhibitor

A highly stereoselective synthesis of the novel tryptase inhibitor BMS-262084 was developed. Key to this synthesis was the discovery and development of a highly diastereoselective demethoxycarbonylation of diester 12 to form the trans-azetidinone 13. BMS-262084 was prepared in 10 steps from D-ornithine in 30% overall yield.