441-28-1

Basic information

• Product Name: 2-(4-FLUORO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID
• Synonyms: 2-(4-FLUORO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID;AKOS BBS-00000700;AKOS AUF0783;IFLAB-BB F0239-0170;CHEMBRDG-BB 5344895;2-(4-fluorophenyl)-4-quinolinecarboxylic acid;2-(4-fluorophenyl)cinchoninic acid
• CAS NO: 441-28-1
• Molecular Formula: C₁₆H₁₀FNO₂
• Molecular Weight: 267.25
• Mol File: 441-28-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 197 °C
• Boiling Point: 453.7°Cat760mmHg
• Flash Point: 228.2°C
• Appearance: /
• Density: 1.344g/cm³
• Vapor Pressure: 5.06E-09mmHg at 25°C
• Refractive Index: 1.663
• PKA: 0.92±0.10(Predicted)
• CAS DataBase Reference: 2-(4-FLUORO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUORO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID(441-28-1)
• EPA Substance Registry System: 2-(4-FLUORO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID(441-28-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 441-28-1(Hazardous Substances Data)

Usage

General Description

2-(4-FLUORO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID is a chemical compound that belongs to the class of organic compounds known as phenylquinolines, which are polycyclic compounds containing a benzene ring linked to a quinoline moiety. The 4-fluoro-phenyl group and quinoline-4-carboxylic acid suggest that this compound may have potential pharmacological properties due to the presence of the functional group -COOH (carboxyl group) which is commonly seen in drug molecules and the fluorine atom, which is often introduced to improve properties of pharmaceuticals such as stability, lipophilicity and bioavailability. However, specific properties, uses or potential applications related to this particular chemical have not been documented in the research literature.

InChI:InChI=1/C16H10FNO2/c17-11-7-5-10(6-8-11)15-9-13(16(19)20)12-3-1-2-4-14(12)18-15/h1-9H,(H,19,20)

Upstream product

• 5467-57-2 2-chloroquinoline-4-carboxylic acid 
• 1765-93-1 4-fluoroboronic acid 
• 42366-35-8 hydroxyimino-N-phenylacetamide 
• 62-53-3 aniline 
• 462-06-6 fluorobenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 127-17-3 2-oxo-propionic acid 
• 91-56-5 indole-2,3-dione 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 1394063-87-6 2-(4-fluorophenyl)-4-(6-methoxy-1H-benzimidazol-2-yl)quinoline 
• 1394063-82-1 4-(1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline 
• 1394063-83-2 4-(5-chloro-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline 

Relevant articles and documents

Synthesis of Novel Quinoline–Benzoxazolinone Ester Hybrids: In Vitro Anti-Inflammatory Activity and Antibacterial Activity

Abstract: A series of novel quinoline-benzoxazolinone ester hybrids were synthesized characterized and assessed for their in vitro anti-inflammatory and antibacterial activity. The in vitro anti-inflammatory activity was executed using protein denaturation assay, proteinase inhibitory assay and human red blood cell membrane stabilization assay. Most of the compounds exhibited potential anti-inflammatory activity. Compound (2-oxobenzo[d]oxazol-3(2H)-yl)methyl-2-(thiophen-2-yl)quinoline-4-carboxylate showed a better anti-inflammatory activity than the standard drugs diclofenac sodium and indomethacin. Furthermore, antibacterial activities of the synthesized compounds were evaluated using resazurin microtiter assay (REMA) and were compared with a positive drug standard chloramphenicol. The compounds demonstrated moderate to potent antibacterial activity. (2-Oxobenzo[d]oxazol-3(2H)-yl)methyl-2-(3,4-dimethoxyphenyl)quinoline-4-carboxylate and (2-oxobenzo[d]oxazol-3(2H)-yl)methyl-2-(2-chlorophenyl)quinoline-4-carboxylate displayed excellent activity against all bacterial strains in comparison to standard chloramphenicol. Moreover, cytotoxicity was performed on MDCK cells using MTT assay and it was found that none of the synthesized derivatives possessed any cytotoxicity.

Novel quinoline substituted triazole compound with bio-activity and synthesis method and application thereof

The invention discloses a novel quinoline substituted triazole compound with bio-activity and a synthesis method and application thereof, and belongs to the technical field of quinoline and triazole derivatives with bio-activity. According to the technica

Design, synthesis and biological evaluation of 4-(imidazolylmethyl)-2-aryl-quinoline derivatives as aromatase inhibitors and anti-breast cancer agents

Some new quinoline derivatives were designed and synthesized to evaluate their biological activities as aromatase inhibitors and anti-breast cancer agents. Cytotoxicity of quinolines 8a-g against human breast cancer MCF-7 and T47D cell lines were evaluate