441715-63-5

Basic information

• Product Name: (5-chloro-2-fluoro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid
• Synonyms: (5-chloro-2-fluoro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid
• CAS NO: 441715-63-5
• Molecular Weight: 361.76
• Mol File: 441715-63-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (5-chloro-2-fluoro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (5-chloro-2-fluoro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid(441715-63-5)
• EPA Substance Registry System: (5-chloro-2-fluoro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid(441715-63-5)

Safety Data

• Hazardous Substances Data: 441715-63-5(Hazardous Substances Data)

Upstream product

• 441717-78-8 ethyl 2-(4-amino-5-chloro-2-fluorophenyl)acetate 
• 79-37-8 oxalyl dichloride 
• 50890-83-0 1-methyl-1H-indazole-3-carboxylic acid 

Relevant articles and documents

VLA-4 INHIBITORS

The present invention relates to a compound represented by the following formula (I): (wherein, W represents WA-A1 -WB - (in which, WA is substituted or unsubstituted aryl, etc., A1 is -NR1-, single bond, -C(O)-, etc., and WB is substituted or unsubstituted arylene, etc.), R is single bond, -NH-, -OCH2-, alkenylene, etc., X is -C(O) -CH2-, etc., and M is, for example, the following formula: (in which, R11, R12 and R13 each independently represents hydrogen, hydroxyl, amino, halogen, etc., R14 is hydrogen or lower alkyl, Y represents -CH2-O-, etc., Z is substituted or unsubstituted arylene, etc., A2 is single bond, etc, and R10 is hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VAL-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like.