441741-66-8

Basic information

• Product Name: Panobinostat Carboxylic Acid Methyl Ester Hydrochloride
• Synonyms: Panobinostat Carboxylic Acid Methyl Ester Hydrochloride;(2E)-3-[4-[[[2-(2-Methyl-1H-indol-3-yl)ethyl]aMino]Methyl]phenyl]-2-propenoic Acid Methyl Ester, Hydrochloride
• CAS NO: 441741-66-8
• Molecular Formula: C₂₂H₂₄N₂O₂*ClH
• Molecular Weight: 383.89116
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 441741-66-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Dichloromethane,
• CAS DataBase Reference: Panobinostat Carboxylic Acid Methyl Ester Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Panobinostat Carboxylic Acid Methyl Ester Hydrochloride(441741-66-8)
• EPA Substance Registry System: Panobinostat Carboxylic Acid Methyl Ester Hydrochloride(441741-66-8)

Safety Data

• Hazardous Substances Data: 441741-66-8(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Intermediate in the preparation of Panobinostat

Upstream product

• 2731-06-8 2-methyltryptamine 
• 1067-74-9 Methyl diethylphosphonoacetate 
• 73291-09-5 4-chloromethylbenzaldehyde 
• 7560-50-1 methyl (2E)-3-(4-formylphenyl)acrylate 
• 441741-65-7 (E)-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]acrylic acid methyl ester 

Downstream Products

• 404950-80-7 panobinostat 

Relevant articles and documents

Synthesis method of panobinostat key intermediate

The invention belongs to the field of medicine synthesis, and particularly relates to a synthesis method of a panobinostat key intermediate. The key intermediate is (E)-3-[4-[[[2-(2-methyl-1H-indole-3-yl)ethyl] amino] methyl] phenyl] methyl acrylate hydrochloride. The method has the advantages that the yield is as high as 85 percent or higher; the impurities are few; the purity is 99.5 percent orhigher; meanwhile, the operation is simple and convenient.

Synthesis method of panobinostat

The invention discloses a synthesis method of panobinostat. The synthesis method comprises a step of synthesizing 2-methyl tryptamine or hydrochloride thereof, namely taking 2-methylindole as a raw material, conducting reaction with chloroacetyl chloride or bromoacetyl bromide, and conducting reaction with potassium phthalimide to obtain the 2-methyl tryptamine. According to the technical scheme adopted by the invention, influence of toxic raw materials on the safety of a panobinostat product is avoided; meanwhile, the invention provides the synthesis method applicable to industrial production.

METHOD OF USE OF DEACETYLASE INHIBITORS

The present invention provides methods of treating and/or preventing pathologic cardiac hypertrophy and heart failure comprising administering hydroxamate compounds which are deacetylase inhibitors.