442851-51-6Relevant articles and documents
Streamlined catalytic asymmetric synthesis of atorvastatin
Kawato, Yuji,Chaudhary, Sandeep,Kumagai, Naoya,Shibasaki, Masakatsu
supporting information, p. 3802 - 3806 (2013/04/24)
An efficient enantioselective synthetic route to atorvastatin was developed based on a direct catalytic asymmetric aldol reaction. The expensive chiral ligand used in the initial aldol reaction was readily recovered (91 %) and reused. Implementation of an oxy-Michael reaction for the construction of the syn-1,3-diol unit eliminated several redundant steps, allowing for rapid access to the common intermediate in six steps (see scheme). Copyright