443305-33-7

Basic information

• Product Name: HPD-OSu
• Synonyms: 2-(2,5-dioxopyrrolidin-1-yloxy)-1,3-dimethyl-3,4,5,6-tetrahydropyrimidin-1-ium hexafluorophosphate(V);PyriMidiniuM,2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,4,5,6-tetrahydro-1,3-diMethyl-,hexafluorophosphate(1-)
• CAS NO: 443305-33-7
• Molecular Formula: C10H16N3O3.PF6
• Molecular Weight: 371.22
• Mol File: 443305-33-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 170-172 °C
• Appearance: /
• CAS DataBase Reference: HPD-OSu(CAS DataBase Reference)
• NIST Chemistry Reference: HPD-OSu(443305-33-7)
• EPA Substance Registry System: HPD-OSu(443305-33-7)

Safety Data

• Hazardous Substances Data: 443305-33-7(Hazardous Substances Data)

Usage

General Description

HPD-OSu is a heterobifunctional crosslinker chemical that is commonly used for conjugating proteins or peptides to carrier proteins and antibodies. It contains both amine-reactive N-hydroxysuccinimide (NHS) ester and maleimide groups, making it suitable for various bioconjugation and crosslinking applications. The NHS ester group reacts with primary amines of proteins, while the maleimide group reacts with sulfhydryl groups of cysteine residues in proteins or peptides. This dual reactivity allows for the selective and efficient conjugation of multiple biomolecules, making HPD-OSu a valuable tool for studying protein-protein interactions, creating antibody-drug conjugates, and developing targeted drug delivery systems.