4437-51-8 Usage
Description
3,4-Hexanedione has a pungent, unpleasant odor reminiscent of
butter and a taste similar to that of diacetyl. May be prepared
synthetically by condensation of ethyl propionate in the presence
of sodium metal, followed by oxidation of the resulting propionin
with copper acetate or ferric chloride.
Chemical Properties
Different sources of media describe the Chemical Properties of 4437-51-8 differently. You can refer to the following data:
1. 3,4-Hexanedione has an aromatic, toasty, burnt, buttery, nutty, caramel-eggy, pungent odor.
2. clear yellow liquid
Occurrence
Reported found in cauliflower, coffee
Preparation
By condensation of ethyl propionate in the presence of sodium metal, followed by oxidation of the resulting propionin
with copper acetate or ferric chloride.
Aroma threshold values
Aroma characteristics at 1.0%: sweet buttery, creamy, slightly cooked caramel and burnt sugary reminiscent of ghee and eggy vanillas.
Taste threshold values
Taste characteristics at 5 ppm: sweet buttery, creamy, pound cake and egg caramel-like with vanilla nuances.
General Description
The dermal irritation and sensitization potential of 3,4-hexanedione (used as constituents of synthetic flavoring agent) was studied using a murine model. The 3,4-hexanedione derivatives inhibited oxoglutarate transport.
Biochem/physiol Actions
Odor at 1.0%
Check Digit Verification of cas no
The CAS Registry Mumber 4437-51-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,3 and 7 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4437-51:
(6*4)+(5*4)+(4*3)+(3*7)+(2*5)+(1*1)=88
88 % 10 = 8
So 4437-51-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H10O2/c1-3-5(7)6(8)4-2/h3-4H2,1-2H3
4437-51-8Relevant articles and documents
Sasaki,S. et al.
, p. 2357 - 2361 (1967)
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Hobday,Short
, p. 612 (1943)
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Synthesis Method of 3,4-hexanedione
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Paragraph 0017; 0019; 0022; 0025, (2018/12/04)
A synthesis method of 3,4-hexanedione comprises a step of 4-hydroxy-3-hexanonen oxidation, and in the step of 4-hydroxy-3-hexanonen oxidation, water is used as a catalyst, acetic acid is used as a cocatalyst, and ozone is used as an oxidizing agent to carry out an oxidation reaction on 4-hydroxy-3-hexanonen, and after the reaction, distillation under reduced pressure is carried out to obtain the 3,4-hexanedione. According to the synthesis method of 3,4-hexanedione in the invention, in the process of 4-hydroxy-3-hexanone oxidation, the 4-hydroxy-3-hexanone is placed in the water, the ozone is used for oxidation on the 4-hydroxy-3-hexanone, and the acetic acid is used as the cocatalyst, so that the entire oxidation reaction process is mild in conditions and simple to operate, no sewage is produced when the final product (3,4-hexanedione) is obtained, and the yield is greatly increased.
Insertion of an Isolable Dialkylstannylene into C-Cl Bonds of Acyl Chlorides Giving Acyl(chloro)stannanes
Lu, Qiong,Yan, Chenting,Xiao, Xu-Qiong,Li, Zhifang,Wei, Ningka,Lai, Guoqiao,Kira, Mitsuo
, p. 3633 - 3637 (2017/10/03)
The reactions of isolable dialkylstannylene 1 with 1-adamantanoyl, 2,2-dimethylpropanoyl, benzoyl, and substituted benzoyl chlorides afford the corresponding acyl(chloro)stannanes in good yields. Similar reactions with more reactive acetyl and propanoyl c
