4441-30-9

Basic information

• Product Name: 3-Morpholinopropanol
• Synonyms: gamma-morpholinopropanol;3-(4-Morpholinyl)-1-propanol, 3-Morpholinopropanol;3-Morpholino-1-propanol;3-Morpholinopropan-1-ol;N-HydroxypropanylMorpholine;3-Morpholinopropanol 3-Morpholino-1-propanol;4-(3-Hydroxypropyl)Morpholine, 98%+;4-(3-Hydroxypropyl)morpholine 95%
• CAS NO: 4441-30-9
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.2
• Product Categories: pharmacetical
• Mol File: 4441-30-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 110-111.5 °C
• Boiling Point: 240-241 °C(lit.)
• Flash Point: 185 °F
• Appearance: /
• Density: 1.049 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00319mmHg at 25°C
• Refractive Index: n20/D 1.4770(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.07±0.10(Predicted)
• CAS DataBase Reference: 3-Morpholinopropanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Morpholinopropanol(4441-30-9)
• EPA Substance Registry System: 3-Morpholinopropanol(4441-30-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36/38
• Safety Statements: 26-36
• RIDADR: 3267
• WGK Germany: 2
• RTECS: QE9104700
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 4441-30-9(Hazardous Substances Data)

Usage

Uses

4-(3-Hydroxypropyl)morpholine may be used in the synthesis of macrocyclic urea compounds, which can act as potent Chk1 inhibitors.

InChI:InChI=1/C7H15NO2/c9-5-1-2-8-3-6-10-7-4-8/h9H,1-7H2

Upstream product

• 696-57-1 N-allylmorpholine 
• 23949-50-0 4-propyl-morpholine 

Downstream Products

• 63916-82-5 4-fluoro-3-iodo-benzoic acid-(3-morpholino-propyl ester) 
• 60439-46-5 3,4,5-trimethoxy-benzoic acid 3-morpholin-4-yl-propyl ester 
• 7357-67-7 4-(3-chloropropyl)morpholine 
• 299914-24-2 4-[3-(2-nitro-phenoxy)-propyl]-morpholine 
• 198962-01-5 4-[N-(3-bromophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline 
• 908002-29-9 2-amino-4-[2,4-dichloro-5-(3-morpholin-4-yl-propoxy)-phenyl]-thieno[2,3-d]pyrimidine-6-carboxylic acid ethylamide 
• 849217-67-0 N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinazolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 849217-74-9 N-[3-fluoro-4-({7-(methyloxy)-6-[(3-morpholin-4-ylpropyl)oxy]quinazolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1171190-92-3 3-(morpholin-1-yl)propyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate 
• 957621-67-9 3-morpholinopropyl 4-methylbenzenesulfonate 

Relevant articles and documents

Platinum-Catalyzed, Terminal-Selective C(sp3)-H Oxidation of Aliphatic Amines

This Communication describes the terminal-selective, Pt-catalyzed C(sp3)-H oxidation of aliphatic amines without the requirement for directing groups. CuCl2 is employed as a stoichiometric oxidant, and the reactions proceed in high yield at Pt loadings as low as 1 mol%. These transformations are conducted in the presence of sulfuric acid, which reacts with the amine substrates in situ to form ammonium salts. We propose that protonation of the amine serves at least three important roles: (i) it renders the substrates soluble in the aqueous reaction medium; (ii) it limits binding of the amine nitrogen to Pt or Cu; and (iii) it electronically deactivates the C-H bonds proximal to the nitrogen center. We demonstrate that this strategy is effective for the terminal-selective C(sp3)-H oxidation of a variety of primary, secondary, and tertiary amines.