4441-50-3

Basic information

• Product Name: N-CYCLOHEXYL-BETA-ALANINE
• Synonyms: RARECHEM AL BO 0397;N-CYCLOHEXYL-B-ALANINE;N-CYCLOHEXYL-BETA-ALANINE;cyclohexylalanine;2-azanyl-3-cyclohexyl-propanoic acid;Cyclohexanepropanoic acid, a-aMino-;3-Cyclohexyl-DL-alanine
• CAS NO: 4441-50-3
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.24
• Mol File: 4441-50-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 307.1°Cat760mmHg
• Flash Point: 139.6°C
• Appearance: /
• Density: 1.075g/cm³
• Vapor Pressure: 0.000167mmHg at 25°C
• Refractive Index: 1.498
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: N-CYCLOHEXYL-BETA-ALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CYCLOHEXYL-BETA-ALANINE(4441-50-3)
• EPA Substance Registry System: N-CYCLOHEXYL-BETA-ALANINE(4441-50-3)

Safety Data

• Hazardous Substances Data: 4441-50-3(Hazardous Substances Data)

Usage

General Description

N-CYCLOHEXYL-BETA-ALANINE, also known as NCA, is a chemical compound that belongs to the class of beta-alanine derivatives. It is a cyclic amino acid that has a cyclohexyl group attached to the beta carbon of the alanine molecule. NCA is commonly used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of polymers and materials. It is also being investigated for its potential therapeutic properties, including its role in the treatment of neurological disorders and as a precursor for the development of new drugs. NCA has also shown promise as a building block for the development of novel peptidomimetic and bioactive compounds. Overall, N-CYCLOHEXYL-BETA-ALANINE has a wide range of applications in various industries and continues to be of interest for its potential pharmacological and medical uses.

InChI:InChI=1/C9H17NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h7-8H,1-6,10H2,(H,11,12)

Upstream product

• 5243-37-8 cyclohexylmethyl-malonic acid 
• 63-91-2 L-phenylalanine 
• 25400-54-8 3-cyclohexyl-D-lactic acid 
• 65644-36-2 3-cyclohexylpropane-1,2-diol 
• 63-91-2 L-phenylalanine 
• 55065-02-6 2-(N-acetylamino)cinnamic acid 
• 204922-64-5 2-Benzyloxycarbonylamino-3-(1-nitro-cyclohexyl)-propionic acid methyl ester 
• 142035-71-0 2-Benzyloxycarbonylamino-3-cyclohexyl-propionic acid methyl ester 
• 2550-36-9 Cyclohexylmethyl bromide 
• 51692-88-7 3-cyclohexyl-2-oxopropionic acid ethyl ester 
• 5962-91-4 3-cyclohexyl-2-oxo-propionic acid 
• 7647-01-0 hydrogenchloride 
• 150-30-1 Phenylalanine 
• 119860-59-2 N-(Benzyloxycarbonyl)-2(S)-amino-3-cyclohexylpropionic acid 

Downstream Products

• 188632-07-7 Fmoc-Cha-OH 
• 119860-59-2 N-(Benzyloxycarbonyl)-2(S)-amino-3-cyclohexylpropionic acid 
• 100400-96-2 2-acetylamino-3-cyclohexylpropanoic acid 
• 144644-00-8 (2R)-2-amino-3-cyclohexyl propanoic acid methyl ester hydrochloride 
• 1428663-34-6 C₂₃H₃₁N₃O₄S₂ 
• 1428663-33-5 C₂₀H₂₇N₃O₄S₂ 

Relevant articles and documents

Direct Synthesis of Free α-Amino Acids by Telescoping Three-Step Process from 1,2-Diols

A practical telescoping three-step process for the syntheses of α-amino acids from the corresponding 1,2-diols has been developed. This process enables the direct synthesis of free α-amino acids without any protection/deprotection step. This method was also effective for the preparation of a 15N-labeled α-amino acid. 1,2-Diols bearing α,β-unsaturated ester moieties afforded bicyclic α-amino acids through intramolecular [3 + 2] cycloadditions. A preliminary study suggests that the resultant α-amino acids are resolvable by aminoacylases with almost complete selectivity.

Self-association-free dimeric cinchona alkaloid organocatalysts: Unprecedented catalytic activity, enantioselectivity and catalyst recyclability in dynamic kinetic resolution of racemic azlactones

Self-association-free, bifunctional, squaramide-based dimeric cinchona alkaloid organocatalysts show unprecedented catalytic activity, enantioselectivity and catalyst recyclability in the dynamic kinetic resolution (DKR) reaction of a broad range of racemic azlactones. The Royal Society of Chemistry 2009.

Enantioselective synthesis of non-natural amino acids using phenylalanine dehydrogenases modified by site-directed mutagenesis

The substrate scope of three mutants of phenylalanine dehydrogenase as biocatalysts for the transformation of a series of 2-oxo acids, structurally related to phenylpyruvic acid, to the analogous -amino acids, non-natural analogues of phenylalanine, has been investigated. The mutant enzymes are more tolerant than the wild type enzyme of the non-natural substrates, especially those with substituents at the 4-position on the phenyl ring. Excellent enantiocontrol resulted in all cases.