4442-94-8

Basic information

• Product Name: Hydroxycyclohexylacetic acid
• Synonyms: 2-Cyclohexyl-2-hydroxyacetic acid;Hydroxycyclohexylacetic acid;α-Hydroxycyclohexaneacetic acid
• CAS NO: 4442-94-8
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.20
• Mol File: 4442-94-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 319.3 °C at 760 mmHg
• Flash Point: 161.1 °C
• Appearance: /
• Density: 1.178 g/cm³
• CAS DataBase Reference: Hydroxycyclohexylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Hydroxycyclohexylacetic acid(4442-94-8)
• EPA Substance Registry System: Hydroxycyclohexylacetic acid(4442-94-8)

Safety Data

• Hazardous Substances Data: 4442-94-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 31, p. 3438, 1966 DOI: 10.1021/jo01348a527

Upstream product

• 134970-42-6 2-chloro-1-cyclohexyl-2-propen-1-ol 
• 75730-04-0 (dimethylphenylsilyl)-1-cyclohexylmethanol 
• 124-38-9 carbon dioxide 
• 1504663-32-4 [cyclohexyl{(trimethylsilyl)oxy}methyl]dimethylphenylsilane 
• 99183-16-1 rac-methyl 2-cyclohexyl-2-hydroxyacetate 
• 110-83-8 cyclohexene 
• 96312-31-1 -tartronsaeure-diethylester 
• 4717-79-7 -tartronsaeure 
• 118-93-4 o-hydroxyacetophenone 
• 17392-15-3 2-hydroxy-3(2H)-benzofuranone 
• 932-66-1 1-cyclohexenyl methyl ketone 
• 134970-67-5 2-Chloro-1-cyclohexyl-2-(toluene-4-sulfinyl)-propan-1-ol 
• 2043-61-0 cyclohexanecarbaldehyde 
• 98-89-5 Cyclohexanecarboxylic acid 

Downstream Products

• 2043-61-0 cyclohexanecarbaldehyde 
• 716362-15-1 benzyl 2-cyclohexyl-2-hydroxyethanoate 
• 99183-16-1 rac-methyl 2-cyclohexyl-2-hydroxyacetate 
• 1033777-05-7 N-(3-benzyloxyphenyl)-2-cyclohexyl-2-hydroxyacetamide 
• 1033777-80-8 C₁₈H₃₂N₂O₄ 
• 1033777-07-9 2-cyclohexyl-2-hydroxy-N-(4-imidazol-1-ylphenyl)acetamide 
• 1373945-76-6 C₂₃H₂₃F₂N₃O 
• 1373945-36-8 C₁₄H₁₅F₂NO₂ 
• 1373945-58-4 C₁₄H₁₇F₂NO₂ 
• 1042110-69-9 cyclohexylhydroxyacetylglycine benzyl ester 
• 121129-41-7 2-(Cyclohexylglycoloyl)-3,6-dihydro-3,6-ethano-2H-1,2-oxazine 
• 121129-37-1 2-(Cyclohexylglycoloyl)-3,6-dihydro-3,6-methano-2H-1,2-oxazine 
• 121129-33-7 (+/-)-Hexahydromandelohydroxamic acid 
• 86582-39-0 2-Benzyl-4-cyclohexylperhydro-1,5,2-dioxazin-3,6-dion 

Relevant articles and documents

Carboxylation with CO2 via brook rearrangement: Preparation of α-hydroxy acid derivatives

In the presence of CsF, a wide range of α-substituted α-siloxy silanes were carboxylated under a CO2 atmosphere (1 atm) via Brook rearrangement. A variety of α-substituents including aryl, alkenyl, and alkyl groups were tolerated to afford α-hydroxy acids in moderate-to-high yields. One-pot synthesis from aldehydes using PhMe2SiLi and CO 2 was also possible, providing α-hydroxy acids without the isolation of an α-hydroxy silane.

Cyclic alkyl substituted glycolides and polylactides therefrom

Cyclic alkyl, particularly cyclohexyl, substituted glycolides and polylactides are described. The polylactides have a high glass transition temperature and improved clarity.

Samarium diiodide-promoted diiodomethylation of carbonyl compounds with iodoform. Synthetic applications of diiodoalcohols

A rapid and effective diiodomethylation of carbonyl compounds using SmI2 and iodoform is described. Transformations of the obtained diiodoalcohols 2 into α-iodoaldehydes 5 and α-hydroxyacids 6 is also reported.