4444-23-9

Basic information

• Product Name: persilic acid
• Synonyms: persilic acid;Persilic;2,5-Dihydroxy-1,4-benzenedisulfonic acid;2,5-dihydroxybenzene-1,4-disulfonic acid;Calcium Dobesilate Hydrate Impurity 1
• CAS NO: 4444-23-9
• Molecular Formula: C₆H₆O₈S₂
• Molecular Weight: 270.237
• EINECS: 224-680-5
• Mol File: 4444-23-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 2.049g/cm³
• Refractive Index: 1.692
• CAS DataBase Reference: persilic acid(CAS DataBase Reference)
• NIST Chemistry Reference: persilic acid(4444-23-9)
• EPA Substance Registry System: persilic acid(4444-23-9)

Safety Data

• Hazardous Substances Data: 4444-23-9(Hazardous Substances Data)

Usage

General Description

Persilic acid is a chemical compound with the molecular formula H2Si2O8. It is a strong oxidizing agent and is typically used as a bleach in the production of paper and textiles. Persilic acid can also be used for the oxidation of organic compounds in chemical synthesis. It is a white, crystalline solid that is soluble in water, and is known for its powerful oxidizing properties. Persilic acid is considered to be a hazardous substance and should be handled with care due to its potential for causing skin and eye irritation, as well as respiratory issues if inhaled. Overall, persilic acid is an important chemical in various industrial processes, particularly in the bleaching and oxidation of organic compounds.

InChI:InChI=1/C6H6O8S2/c7-3-1-5(15(9,10)11)4(8)2-6(3)16(12,13)14/h1-2,7-8H,(H,9,10,11)(H,12,13,14)

Upstream product

• 123-31-9 hydroquinone 
• 106-51-4 p-benzoquinone 
• 88-46-0 dobesilate 
• 14753-51-6 2,5-dibromohydroquinone 
• 121000-02-0 4-methoxyphenol-3-sulfonic acid 

Downstream Products

• 81-64-1 1,4-dihydroxy-9,10-anthracenedione 
• 123-31-9 hydroquinone 
• 57775-25-4 2,5-dihydroxybenzene-1,4-disulphonic acid-bisdiethylamine salt 
• 56534-12-4 hydroquinone-2,5-disulfonate radical 

Relevant articles and documents

Etamsylate and calcium dobesilate impurities, and preparation method and application thereof

The invention discloses four types of etamsylate and calcium dobesilate impurities, namely a 2,5-dihydroxy-1,4-benzene disulfonic acid compound, a 2,4-dihydroxy-1,5-benzene disulfonic acid compound, a2,5-dihydroxy benzene sulfonate compound and a 2,3-dihydroxy benzene sulfonic acid compound, and a preparation method thereof. The purity of all the prepared compound is 96% or more, and the compounds can be used for the quality control of etamsylate and calcium dobesilate bulk drugs and preparations.

Reductive dehalogenation and dehalogenative sulfonation of phenols and heteroaromatics with sodium sulfite in an aqueous medium

Prototropic tautomerism was used as a tool for the reductive dehalogenation of (hetero)aryl bromides and iodides, or dehalogenative sulfonation of (hetero)aryl chlorides and fluorides, using sodium sulfite as the sole reagent in an aqueous medium. This protocol does not require a metal or phase transfer catalyst and avoids using organic solvent as the reaction medium. This method is especially suitable for substrates that readily tautomerize (such as 2-or 4-halogenated aminophenols and 4-halogenated resorcinols), for which dehalogenation or sulfonation proceeds under mild reaction conditions (≤60 °C). As sodium sulfite is an inexpensive, safe, and environmentally less hazardous reagent, this method has at least three potential applications: (i) in the deprotection of halogens as protecting groups, using sodium sulfite as a reducing agent; (ii) in the sulfonation of aromatic halides under mild reaction conditions avoiding hazardous and corrosive reagents/solvents; and (iii) in the transformation of toxic halogenated aromatics into less harmful compounds.

Sulfonation and sulfation on reaction of 1,4-dihydroxybenzene and its methyl ethers in concentrated sulfuric acid

The homogeneous reactions of 1,4-dihydroxybenzene (1), its monomethyl (2) and dimethyl ether (3) and 2-3-sulfonic acid in 68-105percent H2SO4 at 25 deg C have been studied and isomer distributions and rate coefficients for the various subsequent sulfonations, as well as the equilibrium data for the sulfation (-OH -OSO3H), are reported.For 2, the ratio of 2- to 3-sulfonation decreases upon increasing the sulfuric acid concentration from 68-98.5percent H2SO4, due to a gradual change-over in the effective sulfonating entity from H3SO4(1+) to H2S2O7.For 1-2-sulfonic acid (1-2-S), 2-2-S and 2-3-S, the ratios of 5- to 6-sulfonation are all ca. 25:75, whereas 3-2-S only yields the 5-sulfonic acid.Demethylation of the sulfonic acids of 2 and 3 in = 98.5percent H2SO4 is of minor importance, but plays a major role in 105,0 percent H2SO4, the eventual products being the bis(hydrogen sulfate)s 10 and 15, the tricyclic bis(sulfate sulfonate anhydride) 11 and the bicyclic hydrogen sulfate 16.Mechanisms for the sulfodemethylation and for the cyclization of the 2-sulfophenyl hydrogen sulfate moiety to the 1,3,2,4-benzodioxadithiin 2,2,4,4-tetraoxide system are proposed.