4445-13-0

Basic information

• Product Name: 2-(4-Chlorophenyl)-2-hydroxypropionic acid
• Synonyms: 2-(4-Chlorophenyl)-2-hydroxypropionic acid;BENZENEACETIC ACID, 4-CHLORO-A-HYDROXY-A-METHYL-;2-(4-chlorophenyl)-2-hydroxypropanoic acid
• CAS NO: 4445-13-0
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 0
• Mol File: 4445-13-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Chlorophenyl)-2-hydroxypropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlorophenyl)-2-hydroxypropionic acid(4445-13-0)
• EPA Substance Registry System: 2-(4-Chlorophenyl)-2-hydroxypropionic acid(4445-13-0)

Safety Data

• Hazardous Substances Data: 4445-13-0(Hazardous Substances Data)

Usage

General Description

2-(4-Chlorophenyl)-2-hydroxypropionic acid, also known as ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to reduce pain, inflammation, and fever. It works by inhibiting the formation of prostaglandins, which are chemicals in the body that cause pain and inflammation. Ibuprofen is often used to alleviate symptoms associated with conditions such as arthritis, menstrual cramps, and minor injuries. It is available over-the-counter and in prescription-strength formulations, and is generally well tolerated by most individuals when taken at recommended doses. However, like all medications, ibuprofen can have potential side effects and interactions with other drugs, so it is important to use it under the guidance of a healthcare professional.

Upstream product

• 127-17-3 2-oxo-propionic acid 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 67-66-3 chloroform 
• 99-91-2 para-chloroacetophenone 
• 75-69-4 trichlorofluoromethane 
• 917-64-6 methyl magnesium iodide 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 124-38-9 carbon dioxide 
• 102877-35-0 2-(4-chlorophenyl)-propane-1,2-diol 
• 53066-09-4 2-hydroxy-2-(4-chlorophenyl)-propanenitrile 

Downstream Products

• 938-95-4 2-(4-Chloro-phenyl)-propionic acid 
• 282721-24-8 2-(4-chlorophenyl)-2-hydroxy-N-[2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl]propionamide 
• 162405-17-6 N-tert-Butoxy-2-(4-chlorphenyl)-2-hydroxypropanamid 

Relevant articles and documents

Synthesis of α-hydroxycarboxylic acids from various aldehydes and ketones by direct electrocarboxylation: A facile, efficient and atom economy protocol

In present work, the formation of α-hydroxycarboxylic acids have been described from various aromatic aldehydes and ketones via direct electrocarboxylation method with 80-92% of yield without any side product and can be purified by simple recrystallization using sacrificial Mg anode and Pt cathode in an undivided cell, CO2at (1 atm) was continuously bubbled in the cell throughout the reaction using tetrapropylammonium chloride as a supporting electrolyte in acetonitrile. The synthesized compounds obtained in fair to excellent yield with a high level of purity. The characterization of electrocarboxylated compounds was done with spectroscopic techniques like IR, NMR (1H & 13C), mass and elemental analysis.

Facile one-pot preparation of 2-arylpropionic and arylacetic acids from cyanohydrins by treatment with aqueous HI

A novel one-pot two-step procedure has been developed to synthesize highly substituted 2-arylpropionic and arylacetic acids, by treatment with aqueous HI, from cyanohydrins. The hydrogenolytic reduction of α-hydroxy-2-arylpropionic acids was the key step of the process and the optimization of the reaction conditions led to identify aqueous HI as an appropriate and selective reagent for the reductive deoxygenation of cyanohydrins. The synthetic route described a general and efficient strategy for the preparation of large libraries of phenylacetic and phenylpropionic acids derivatives.

Synthesis and properties of 3-alkylsubstituted 1-alkoxy(hydroxy)indolin-2-ones

N-alkoxy-2-aryl-2-hydroxycarboxamides 3 are smoothly converted into 3-alkylsubstituted 1-alkoxyindolin-2-ones (2A) by dicyclohexylcarbodiimide in boiling trichloroethene. The acidolysis of the 1-tert-butoxyindolin-2-ones 2Ab, g, i, k as well as the 1-alko