4446-91-7

Basic information

• Product Name: (3-chloro-1-methoxypropyl)benzene
• Synonyms: (3-chloro-1-methoxypropyl)benzene
• CAS NO: 4446-91-7
• Molecular Formula: C₁₀H₁₃ClO
• Molecular Weight: 184.66262
• EINECS: 224-687-3
• Mol File: 4446-91-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 263.92°C (rough estimate)
• Flash Point: 104.3°C
• Appearance: /
• Density: 1.0639 (rough estimate)
• Vapor Pressure: 0.0609mmHg at 25°C
• Refractive Index: 1.5220 (estimate)
• CAS DataBase Reference: (3-chloro-1-methoxypropyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (3-chloro-1-methoxypropyl)benzene(4446-91-7)
• EPA Substance Registry System: (3-chloro-1-methoxypropyl)benzene(4446-91-7)

Safety Data

• Hazardous Substances Data: 4446-91-7(Hazardous Substances Data)

Usage

General Description

(3-chloro-1-methoxypropyl)benzene, also known as 1-Chloro-3-methoxy-2-propylbenzene, is a chemical compound commonly used in the synthesis of pharmaceuticals and agrochemicals. It belongs to the family of alkylbenzenes, which are aromatic hydrocarbons containing a benzene ring substituted with one or more alkyl groups. (3-chloro-1-methoxypropyl)benzene is a colorless to pale yellow liquid with a molecular formula C9H11ClO, and a molecular weight of 168.63 g/mol. It is primarily used as an intermediate in the manufacturing of various compounds and is known to have potential therapeutic properties in medical treatments. However, (3-chloro-1-methoxypropyl)benzene should be handled with care due to its potential hazards, and proper safety measures should be taken when working with this chemical.

InChI:InChI=1/C10H13ClO/c1-12-10(7-8-11)9-5-3-2-4-6-9/h2-6,10H,7-8H2,1H3

Upstream product

• 4446-86-0 1,3-dichloro-1-methoxy-propane 
• 18776-12-0 3-chloro-1-phenyl-propan-1-ol 
• 74-88-4 methyl iodide 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 21763-00-8 1-bromo-3-chloro-1-phenylpropane 

Downstream Products

• 1332887-38-3 1-azido-3-chloro-1-phenylpropane 
• 4457-56-1 (+/-)4-Chlor-1-methoxy-1-phenyl-pentan 
• 4447-01-2 opt.-inakt. 5-Methoxy-5-phenyl-pentan-2-ol 
• 14547-95-6 1,3-diphenyl-1-methoxypropane 
• 26278-67-1 1,3-dimethoxy-1-phenylpropane 

Relevant articles and documents

Chemoselective and direct functionalization of methyl benzyl ethers and unsymmetrical dibenzyl ethers by using iron trichloride

Methyl and benzyl ethers are widely utilized as protected alcohols due to their chemical stability, such as the low reactivity of the methoxy and benzyloxy groups as leaving groups under nucleophilic conditions. We have established the direct azidation of chemically stable methyl and benzyl ethers derived from secondary and tertiary benzyl alcohols. The present azidation chemoselectively proceeds at the secondary or tertiary benzylic positions of methyl benzyl ethers or unsymmetrical dibenzyl ethers and is also applicable to direct allylation, alkynylation, and cyanation reactions, as well as the azidation. The present methodologies provide not only a novel chemoselectivity but also the advantage of shortened synthetic steps, due to the direct process without the deprotection of the methyl and benzyl ethers. Ethers exchanged: Methyl and benzyl ethers are chemically stable and generally tolerant under nucleophilic substitution conditions. Iron-catalyzed direct functionalizations (e.g., azidation, allylation, alkynylation, and cyanation) of methyl and benzyl ethers derived from secondary and tertiary benzyl alcohols were established with excellent regioselectivities (see scheme; PG: protecting group; Bn: benzyl; Nu: nucleophile; TMS: trimethylsilyl). Copyright