4449-43-8

Basic information

• Product Name: ALPHA-THYMIDINE
• Synonyms: 1-[2-DEOXY-ALPHA-D-RIBOFURANOSYL]-5-METHYLURACIL;ALPHA-THYMIDINE;A-thymidine;alpha-thymidinecrystalline;1-(2-Deoxy-α-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione;1-(2-Deoxy-α-D-erythro-pentofuranosyl)thymine
• CAS NO: 4449-43-8
• Molecular Formula: C₁₀H₁₄N₂O₅
• Molecular Weight: 242.23
• Mol File: 4449-43-8.mol
• Article Data: 31

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.452g/cm³
• Refractive Index: 1.584
• CAS DataBase Reference: ALPHA-THYMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA-THYMIDINE(4449-43-8)
• EPA Substance Registry System: ALPHA-THYMIDINE(4449-43-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 4449-43-8(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

Different sources of media describe the Uses of 4449-43-8 differently. You can refer to the following data:
1. α-Thymidine (α-Thymidine) is the unnatural epimer of thymidine.
2. α-Thymidine is an epimer of Thymidine (T412000) and can be used in the synthesis of oligonucleotides containing α-Thymidine.

InChI:InChI=1/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8-/m0/s1

Upstream product

• 50-89-5 thymidine 
• 153737-54-3 3'-5'-di-O-acetyl-α-D-thymidine 
• 65-71-4 2,4-dihydroxy-5-methylpyrimidine 
• 3080-30-6 1-O-acetyl-2,3,5-tri-O-benzoyl-β-L-ribofuranose 
• 65-71-4 thymin 
• 50571-26-1 5'-DMT-thymidine-3'-H-phosphonate 
• 68027-40-7 2,4-di-O-trimethylsilylthymine 
• 433733-94-9 3',5'-di-O-acetyl-β-L-thymidine 
• 1062488-85-0 C₂₆H₂₆N₂O₇ 
• 143156-51-8 C₁₂H₁₈N₂O₆ 
• 817622-48-3 C₂₀H₃₀N₂O₇ 
• 40093-95-6 1-(3′,5′-di-O-benzoyl-2′-deoxy-αβ-L-ribofuranosyl)thymine 
• 3056-13-1 1-(2-deoxy-3,5-di-p-toluoyl-β-L-ribose)-5-methyluracil 
• 7791-71-1 5'-O-tritylthymidine 

Downstream Products

• 52474-36-9 1-[2-deoxy-5-O-(4-methoxytrityl)-α-D-erythro-pentofuranosyl]thymine 
• 1416441-60-5 C₁₆H₁₈N₄O₈S 
• 1416442-52-8 C₂₄H₂₅ClN₄O₆ 
• 1416442-54-0 C₂₄H₂₅ClN₄O₆ 
• 1416442-56-2 C₂₅H₂₈N₄O₇ 
• 1416442-58-4 C₂₈H₃₄N₄O₆ 
• 1416441-63-8 C₁₇H₁₈N₄O₇ 
• 1416441-64-9 C₁₇H₂₀N₄O₆ 
• 1416441-66-1 C₁₈H₂₂N₄O₅ 
• 1416441-68-3 N-(5'-deoxy-α-thymidin-5'-yl)-N'-phenylurea 
• 1416441-69-4 N-(5'-deoxy-α-thymidin-5'-yl)-N'-(2-chlorophenyl)urea 
• 1416441-71-8 N-(5'-deoxy-α-thymidin-5'-yl)-N'-(3-chlorophenyl)urea 
• 1416441-72-9 N-(5'-deoxy-α-thymidin-5'-yl)-N'-(4-chlorophenyl)urea 
• 1416441-73-0 N-(5'-deoxy-α-thymidin-5'-yl)-N'-(4-bromophenyl)urea 

Relevant articles and documents

Meteorite-catalyzed intermoleculartrans-glycosylation produces nucleosides under proton beam irradiation

Di-glycosylated adenines act as glycosyl donors in the intermoleculartrans-glycosylation of pyrimidine nucleobases under proton beam irradiation conditions. Formamide and chondrite meteorite NWA 1465 increased the yield and the selectivity of the reaction

Synthesis method of beta-thymidine

The invention discloses a synthesis method of beta-thymidine. The synthesis method takes trimethylchlorosilane and 5-methyluracil as raw materials to react; in a reaction line process, tetraacetylribose, trifluoromethanesulfonic acid, N,N-dimethylformamide and acetylchloride are introduced; then hydrogenation reaction and hydrolysis reaction are carried out to finally obtain a beta-thymidine finished product and the yield is 89 percent. Compared with an existing synthesis method, the synthesis method of the beta-thymidine has the advantages that the price of raw materials is low, the content of the beta-thymidine in the final product is high, and pollution to the environment in a production process is small; in a synthesis process, the content of generated impurities is less. According to the synthesis method disclosed by the invention, an obtained result is stable and the operation is simple; demands on equipment and preparation environments are not strict so that large-scale popularization is facilitated.

Method for preparing high-purity telbivudine compound

The invention belongs to the technical field of medicine and provides a method for preparing a high-purity telbivudine compound. The method includes the steps that an LTD-4 compound serves as the raw material and reacts with thymine subjected to silicification protection, and an intermediate, namely an LTD-5 compound, can be obtained; then, through deprotection reaction, the telbivudine compound is obtained after post-processing, wherein MeONa serves as an alkaline reagent of the deprotection reaction, and strong-acidity resin serves as a dealkalization reagent. The method simplifies the production process, the yield of each step is high, and a target product high in purity and yield is obtained. Please see the structural formula in the description.