445476-82-4

Basic information

• Product Name: N,N-dimethyl-(1-phenyl-2,2,2-trifluoroethoxytrimethylsilyl)-amine
• Synonyms: N,N-dimethyl-(1-phenyl-2,2,2-trifluoroethoxytrimethylsilyl)-amine
• CAS NO: 445476-82-4
• Molecular Weight: 291.389
• Mol File: 445476-82-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-(1-phenyl-2,2,2-trifluoroethoxytrimethylsilyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-(1-phenyl-2,2,2-trifluoroethoxytrimethylsilyl)-amine(445476-82-4)
• EPA Substance Registry System: N,N-dimethyl-(1-phenyl-2,2,2-trifluoroethoxytrimethylsilyl)-amine(445476-82-4)

Safety Data

• Hazardous Substances Data: 445476-82-4(Hazardous Substances Data)

Upstream product

• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 611-74-5 N,N-dimethylbenzamide 
• 2083-91-2 N,N-Dimethyltrimethylsilylamine 
• 434-45-7 2,2,2-Trifluoroacetophenone 

Downstream Products

• 379-18-0 1,1-diphenyl-2,2,2-trifluoroethanol 
• 446-65-1 2,2,2-trifluoro-1-(4-methylphenyl)ethanol 
• 80418-12-8 1-(4-bromo-phenyl)-2,2,2-trifluoro-ethanol 
• 908603-36-1 phenyl-(2,2,2-trifluoro-1-phenyl-ethyl)-trimethylsilanylamine 
• 17556-42-2 2,2,2-trifluoro-1-(4-methoxyphenyl)ethanol 
• 340-04-5 1-phenyl-2,2,2-trifluoromethylethanol 
• 20445-36-7 2-hydroxy-2-phenyl-3,3,3-trifluoro-2-propanoic acid methyl ester 
• 70783-48-1 2-(2,2,2-trifluoro-1-hydroxyethyl)furan 

Relevant articles and documents

One-Pot Trifluoromethylative Functionalization of Amides: Synthesis of Trifluoromethylated Bis(indolyl)arylmethanes and Triarylmethanes

Efficient and general one-pot trifluoromethylative functionalization of amides has been accomplished for the synthesis of various trifluoromethylated bis(indolyl)arylmethane, utilizing trifluoromethyltrimethylsilane and substituted indoles as nucleophiles. The developed reaction involves the in situ generation and trapping of a trifluoromethylated iminium ion, derived from the trifluoromethylated hemiaminal of amide, with various substituted indoles. This method has been successfully extended to the synthesis of diverse trifluoromethylated triarylmethanes employing phenols as nucleophiles. Furthermore, the potential of the method was demonstrated via the two-step synthesis of a trifluoromethylated analog of a hypolipidemic and anti-obesity agent.

Some studies on nucleophilic trifluoromethylation using the shelf-stable trifluoromethylacetophenone-N,N-dimethyltrimethylsilylamine adduct

The simple thermal addition product of N,N-dimethyltrimethylsilylamine with 2,2,2-trifluoroacetophenone provides a shelf-stable reagent for nucleophilic trifluoromethylation of both the carbonyl and the imine group.