446-09-3Relevant articles and documents
Method for preparing 2-bromo-5-fluoroaniline
-
, (2020/12/31)
The invention discloses a method for preparing 2-bromo-5-fluoroaniline, belonging to the field of organic chemical synthesis. The preparation method comprises the following steps: with 4-fluoroanilineas a raw material, reacting 4-fluoroaniline with acetic anhydride to generate 4-fluoroacetanilide; performing nitrification; replacing acetamido groups with bromine; and reducing nitro groups. Thus,the 2-bromo-5-fluoroaniline with high yield and high purity is prepared. The method has the advantages of high product yield, high purity, easy availability of raw materials and simple operation, andis beneficial to industrial production.
Synthesis method of 2-bromo-5-fluoronitrobenzene
-
Paragraph 0039-0042, (2018/11/22)
The invention discloses a synthesis method of 2-bromo-5-fluoronitrobenzene and belongs to the field of organic chemistry. The synthesis method comprises the steps: adding m-nitrofluorobenzene and dibromohydantoin into an organic solvent, carrying out heating, dropwise adding a sulfuric acid aqueous solution, carrying out a further heat insulation reaction after finishing dropping, and then, carrying out cooling to room temperature; separating an organic layer, carrying out washing to be neutral, and then, carrying out reduced-pressure desolvation to obtain a target product. A reaction system of the method is simple, raw materials are available, the sulfuric acid aqueous solution can be indiscriminately used many times, the wastewater content is low, and a simple and green approach is provided for the synthesis of the compound.
Synthetic method of aryl halide taking aryl carboxylic acid as raw material
-
Paragraph 0067, (2018/01/03)
A synthetic method of an aryl halide taking aryl carboxylic acid as a raw material is characterized in that a corresponding aryl halide is formed by carrying out substitution reaction on an aryl carboxylic acid compound and haloid salt MX in an organic solvent under the condition that oxygen, a silver catalyst, a copper additive and a bidentate nitrogen ligand exist, wherein M in MX represents alkali metal or alkaline earth metal, and X represents F, Cl, Br or I. Compared with a conventional aryl halide synthetic method, the synthetic method disclosed by the invention has the obvious advantages that reaction raw materials (comprising aryl carboxylic acid and MX) are cheap and easy to obtain, the using amount of a metal catalyst is small, pollution to the environment when the oxygen is used as an oxidant is the smallest, good tolerance to various functional groups on an aromatic ring is obtained, the yield is high, and the like. The synthetic method disclosed by the invention can be widely applied to synthesis in the fields of medicine, materials, natural products and the like in industry and academia.