446252-18-2Relevant articles and documents
3,4-Dihydropyrimidin-2(1 H)-ones as Antagonists of the Human A2BAdenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition
Majellaro, María,Jespers, Willem,Crespo, Abel,Nú?ez, María J.,Novio, Silvia,Azuaje, Jhonny,Prieto-Díaz, Rubén,Gioé, Claudia,Alispahic, Belma,Brea, José,Loza, María I.,Freire-Garabal, Manuel,Garcia-Santiago, Carlota,Rodríguez-García, Carlos,García-Mera, Xerardo,Caama?o, Olga,Fernandez-Masaguer, Christian,Sardina, Javier F.,Stefanachi, Angela,El Maatougui, Abdelaziz,Mallo-Abreu, Ana,?qvist, Johan,Gutiérrez-De-Terán, Hugo,Sotelo, Eddy
supporting information, p. 458 - 480 (2021/01/13)
We present and thoroughly characterize a large collection of 3,4-dihydropyrimidin-2(1H)-ones as A2BAR antagonists, an emerging strategy in cancer (immuno) therapy. Most compounds selectively bind A2BAR, with a number of potent and selective antagonists fu