4483-47-0

Basic information

• Product Name: 1-(3,4-dimethoxyphenyl)-3-ethyl-5,6-dimethoxy-2-methyl-2,3-dihydro-1H-indene
• CAS NO: 4483-47-0
• Molecular Formula: C₂₂H₂₈O₄
• Molecular Weight: 356.4553
• Mol File: 4483-47-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 448.5°C at 760 mmHg
• Flash Point: 111.3°C
• Density: 1.06g/cm³
• Vapor Pressure: 8.18E-08mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: 1-(3,4-dimethoxyphenyl)-3-ethyl-5,6-dimethoxy-2-methyl-2,3-dihydro-1H-indene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dimethoxyphenyl)-3-ethyl-5,6-dimethoxy-2-methyl-2,3-dihydro-1H-indene(4483-47-0)
• EPA Substance Registry System: 1-(3,4-dimethoxyphenyl)-3-ethyl-5,6-dimethoxy-2-methyl-2,3-dihydro-1H-indene(4483-47-0)

Safety Data

• Hazardous Substances Data: 4483-47-0(Hazardous Substances Data)

Usage

General Description

1-(3,4-dimethoxyphenyl)-3-ethyl-5,6-dimethoxy-2-methyl-2,3-dihydro-1H-indene, also known as Glaucine, is a chemical compound with a complex structure. It is a natural alkaloid found in a variety of plant species, particularly in the Papaveraceae family, and has been used for its potential pharmaceutical properties. Glaucine has been studied for its potential anti-inflammatory, antitussive, and bronchodilator effects, making it a potential candidate for the treatment of respiratory conditions. Additionally, it has shown potential as an analgesic and has been investigated for its role in modulating the activity of certain neurotransmitter receptors in the brain. Further research is needed to fully understand the pharmacological properties and potential therapeutic uses of Glaucine.

Upstream product

• 93-16-3 Methylisoeugenol 
• 522-09-8 1β-ethyl-5-hydroxy-6-methoxy-3α-(4'-hydroxy-3'-methoxyphenyl)-2β-methylindane 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 4043-71-4 isosafrole 
• 22688-82-0 (+/-)-5r-ethyl-7t-benzo[1,3]dioxol-5-yl-6c-methyl-6,7-dihydro-5H-indeno[5,6-d][1,3]dioxole 
• 6379-72-2 1,2-dimethoxy-4-(E)-propenylbenzene 
• 120-58-1 isosafrole 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 1208-70-4 (+/-)-3.4-dimethoxy-1-(erythro-1.2-dibromo-propyl)-benzene 
• 1835-04-7 ethyl 3,4-dimethoxyphenyl ketone 
• 7664-93-9 sulfuric acid 
• 7647-01-0 hydrogenchloride 
• 22688-82-0 diisosafrole 

Downstream Products

• 82005-32-1 (+/-)-5.6-dimethoxy-2c-methyl-1r-ethyl-3c-(6-bromo-3.4-dimethoxy-phenyl)-indan 
• 15462-91-6 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]pentan-2-one 
• 7249-36-7 2-(3,4-Dimethoxy-benzoyl)-4,5-dimethoxy-benzoic acid 
• 93-07-2 Veratric acid 
• 120-80-9 benzene-1,2-diol 
• 19452-42-7 3-Ethyl-5,6-dihydroxy-2-methyl-1-(3',4'-dihydroxyphenyl)-indan 

Relevant articles and documents

Stereocontrolled syntheses of (-)- And (+)-γ-diisoeugenol along with optically active eight stereoisomers of 7,8′-epoxy-8,7′-neolignan

It was shown that reduction of the tertiary benzylic hydroxy group of (2R,3S,4R,5S)-3,5-bis(4-benzyloxy-3-methoxyphenyl)-2,4-dimethyltetrahydro-3-furanol 17 followed by the intramolecular Friedel-Crafts reaction gave exclusively indane with (7S,7′S,8R,8′R)-2,7′-cyclo-7,8′-neolignan structure 18 along with (7S,7′R,8S,8′R)-7,8′-epoxy-8,7′-neolignan structure 19. Indane 18 was converted to (-)-γ-diisoeugenol ((-)-4). On the other hand, (2S,3R,4R,5S)-3,5-bis(4-benzyloxy-3-methoxyphenyl)-2,4-dimethyltetrahydro-3-furanol 22 did not afford indane, but the tetrahydrofuran structure with (7S,7′S,8S,8′S)-7,8′-epoxy-8,7′-neolignan structure 23 and 7′-epi-23.

holds the non-rope to divide method for the preparation of intermediates

The invention relates to a preparation method of a tofisopam intermediate 3-[2-(3,4-dimethoxy benzoic acyl)-4,5-dimethoxyphenyl]-penta-2-ketone, and belongs to the technical field of pharmaceutical synthesis. The method comprises the following step: carrying out reaction on 1-(3,4-dimethoxy-phenyl)-3-ethyl-5,6-dimethoxy-2-methyl-indan as an initial material, copper compounds as catalysts, and hydrogen peroxide as an oxidant under an acid condition, so as to prepare the tofisopam intermediate 3-[2-(3,4-dimethoxy benzoic acyl)-4,5-dimethoxyphenyl]-penta-2-ketone. According to the preparation method, the content of heavy metals in the wastewater is greatly lowered, chromium compounds with carcinogenesis are avoided, the production capacity of tofisopam is released, and the environment is protected.

Anomalous behaviour of Pd(II) on phenylpropanoids

Exposure of phenylpropanoids like methyleugenol, eugenol and methylchavicol to Pd(II) chloride in acetic acid results in α,β linked unsymmetrical dimers. Dimeric coupling is characteristic of phenylpropanoids whereas cyclisation to indanes require the pre