44843-89-2

Basic information

• Product Name: 5-hydroxyhexanoic acid
• Synonyms: Hexanoic acid, 5-hydroxy-;5-Hydroxycaproate
• CAS NO: 44843-89-2
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.08
• Mol File: 44843-89-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 263.141 °C at 760 mmHg
• Flash Point: 127.196 °C
• Appearance: /
• Density: 1.101 g/cm³
• Vapor Pressure: 0.00148mmHg at 25°C
• Refractive Index: 1.46
• CAS DataBase Reference: 5-hydroxyhexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxyhexanoic acid(44843-89-2)
• EPA Substance Registry System: 5-hydroxyhexanoic acid(44843-89-2)

Safety Data

• Hazardous Substances Data: 44843-89-2(Hazardous Substances Data)

Usage

Description

5-Hydroxyhexanoic acid, also known as a medium-chain fatty acid, is a derivative of hexanoic acid with a hydroxy group substitution at the 5th position. This unique structure endows it with specific properties that make it suitable for various applications across different industries.

Uses

Used in Pharmaceutical Industry:
5-Hydroxyhexanoic acid is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of drugs targeting specific medical conditions.
Used in Cosmetic Industry:
5-Hydroxyhexanoic acid is used as an active ingredient in the cosmetic industry, particularly in skincare products. Its properties make it suitable for improving skin hydration, promoting skin health, and potentially offering anti-aging benefits.
Used in Chemical Synthesis:
5-Hydroxyhexanoic acid is used as a building block in the synthesis of various chemicals and materials. Its unique structure can be utilized to create novel compounds with specific properties for use in different applications.
Used in Research and Development:
5-Hydroxyhexanoic acid is used as a research tool in the development of new drugs, materials, and technologies. Its unique properties make it an interesting candidate for studying various biological and chemical processes.
Used in Biotechnology:
5-Hydroxyhexanoic acid can be used in biotechnological applications, such as the production of bio-based materials or the development of new biocatalytic processes. Its unique structure can be exploited to create innovative solutions in the field of biotechnology.

InChI:InChI=1/C6H12O3/c1-5(7)3-2-4-6(8)9/h5,7H,2-4H2,1H3,(H,8,9)

Upstream product

• 3128-06-1 5-ketohexanoic acid 

Downstream Products

• 43112-32-9 (R)-(+)-δ-methyl-δ-valerolactone 
• 16320-13-1 (S)-6-methyl-tetrahydro-pyran-2-one 

Relevant articles and documents

Chain terminators, the use thereof for nucleic acid sequencing and synthesis and a method of their preparation

The invention relates to compounds of general structure (I) or salts thereof, wherein B is a nucleobase, X and Z independently are oxygen or sulphur, Y is hydrogen or hydroxy, which optionally may be protected, R1 is hydrocarbyl, which optionally is substituted with a functional group, R2 is hydrogen or hydrocarbyl, which optionally is substituted with a functional group, A is an electron withdrawing or electron donating group capable of moderating the acetal stability of compound (I), L1 and L2 are hydrocarbon linkers, which may be the same or different, L2, when present, being either (i) connected to L1 via the group A, or (ii) directly connected to L1, the group A then being connected to one of linkers L1 and L2, F is a dye label, Q is a coupling group for F, and l, m and n independently are 0 or 1, with the proviso that l is 1 when m is 1, and l is 1 and m is 1 when n is 1. The compounds of formula (I) are useful as deactivatable chain extension terminators. The invention also relates to the use of the compounds (I) in nucleic acid synthesis and nucleic acid sequencing as well as to a method of preparing compounds of Formula (I).

Identification of 5-hydroxyhexanoic acid in the urine of twin siblings with a Reye's-like syndrome associated with dicarboxylic aciduria and hypoglycaemia and with similarities to Jamaican vomiting sickness

Twin male infant siblings who presented in Harrow, UK, with a Reye's-like syndrome associated with profound hypoglycaemia, vomiting, diarrhoea, coma and death in one child, with dicarboxylic aciduria, and similarities to Jamaican vomiting sickness (hypoglycin toxicity) have been shown to excrete large amounts of a previously unrecorded urinary organic acid. This has been identified as 5-hydroxyhexanoic acid by gas chromatography mass spectrometry using a synthesized standard. Concentrations observed were 340 and 330 mg g-1 creatinine in the two patients. The metabolic precursor of the urinary acid is suggested to be hex-4-enoic acid, a probable chemical toxin closely related to the active organic acid metabolite of hypoglycin. The possibility of ω-1 oxidation of hexanoic acid to 5-hydroxyhexanoic acid in these and other patients with dicarboxylic acidurias is also discussed.