4491-92-3

Basic information

• Product Name: 1-(2-CYANOETHYL)-4-METHYLPIPERAZINE
• Synonyms: 4-METHYL-1-PIPERAZINEPROPANENITRILE;1-(2-CYANOETHYL)-4-METHYLPIPERAZINE;3-(4-Methylpiperazino)propionitrile;1-Piperazinepropanenitrile,4-methyl-(9CI);4-Methyl-1-piperazinepropionitrile, 98%
• CAS NO: 4491-92-3
• Molecular Formula: C₈H₁₅N₃
• Molecular Weight: 153.22
• Product Categories: PIPERIDINE
• Mol File: 4491-92-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 97-98 °C
• Boiling Point: 134-136°C 13mm
• Flash Point: 134-136°C/13mm
• Appearance: /
• Density: 0.981 g/cm³
• Vapor Pressure: 0.0059mmHg at 25°C
• Refractive Index: 1.4700
• PKA: 7.53±0.10(Predicted)
• BRN: 117453
• CAS DataBase Reference: 1-(2-CYANOETHYL)-4-METHYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-CYANOETHYL)-4-METHYLPIPERAZINE(4491-92-3)
• EPA Substance Registry System: 1-(2-CYANOETHYL)-4-METHYLPIPERAZINE(4491-92-3)

Safety Data

• Statements: 20/21/22-36/38
• Safety Statements: 26-36/37/39-36/37
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 4491-92-3(Hazardous Substances Data)

Usage

General Description

1-(2-Cyanoethyl)-4-methylpiperazine is a chemical compound that belongs to the class of piperazine derivatives. It is primarily used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. This chemical is known for its ability to act as a versatile building block in the creation of complex molecules, due to its structural and functional properties. Its molecular structure consists of a piperazine core with a cyanoethyl group and a methyl group attached to it, making it a versatile substrate for the synthesis of various bioactive compounds. It is important to handle this compound with caution, as it may pose health hazards and requires proper safety measures during its handling and usage.

InChI:InChI=1/C8H15N3/c1-10-5-7-11(8-6-10)4-2-3-9/h2,4-8H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 107-13-1 acrylonitrile 

Downstream Products

• 4572-03-6 3-(N-methylpiperazino)propylamine 
• 90331-23-0 1-(3'-Dimethylaminopropyl)-4-methyl-piperazin 
• 108372-23-2 3-<4-Methyl-piperazinyl-(1)>-propionsaeureamid-oxim 
• 73816-65-6 2-[3-(4-methyl-piperazino)-propyl]-(3ar,7ac)-2,3,3a,4,7,7a-hexahydro-1H-isoindole 
• 73839-58-4 2-[3-(4-methyl-piperazino)-propyl]-(3ar,7ac)-3a,4,7,7a-tetrahydro-isoindole-1,3-dione 
• 1100793-89-2 N-[5-chloro-2-(phenylthio)phenyl]-3-(4-methylpiperazine-1-yl)-propanamidine 

Relevant articles and documents

Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase

The synthesis and evaluation of 3,5-disubstituted benzofuran derivatives as time-dependent inhibitors of the protozoan oxidoreductase trypanothione reductase are reported. These molecules were designed as simplified mimetics of the naturally occurring spermidine-bridged macrocyclic alkaloid lunarine 1, a known time-dependent inhibitor of trypanothione reductase. In this series of compounds the bis-polyaminoacrylamide derivatives 2-4 were all shown to be competitive inhibitors, but only the bis-4-methyl-piperazin-1-yl-propylacrylamide derivative 4 displayed time-dependent activity. The kinetics of time dependent inactivation of trypanothione reductase by 1 and 4 have been determined and are compared and discussed herein.

PROCESS FOR THE MANUFACTURE OF 3-PIPERAZIN-1-YL-PROPYLAMINE DERIVATIVES

The invention relates to the manufacture of a compound of formula (I), wherein R1 is defined as in the description and in the claims.

An efficient synthesis of 2-aminothiophenes via the gewald reaction catalyzed by an N-methylpiperazine-functionalized polyacrylonitrile fiber

A new N-methylpiperazine-functionalized polyacrylonitrile fiber has been developed to catalyze the Gewald reaction between 2,5-dihydroxy-1,4-dithiane and activated nitriles to afford 3-substituted 2-aminothiophenes in good to excellent yields (65-91%). Low catalyst loading (8.0 mol%), simple procedure, high yields, excellent recyclability, and reusability (up to 10 times with minimal loss of catalytic activity) are attractive features of this fiber catalyst. Georg Thieme Verlag Stuttgart · New York.